Product image of Levobupivacaine Altan Pharma (Levobupivacaine) supplied by GNH India

Levobupivacaine Altan Pharma

Active Ingredient:
Levobupivacaine
Origin:
EU

Levobupivacaine Altan Pharma (Levobupivacaine)

Levobupivacaine, the active ingredient in Levobupivacaine Altan Pharma, is a local anesthetic (amide type) presented as a sterile solution for epidural, infiltration, and intrathecal use. It provides regional anesthesia for surgical procedures and pain management in adult patients. It is indicated for use in adult patients undergoing surgery, obstetric procedures, and postoperative pain control.

GNH India supplies Levobupivacaine Altan Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Altan Pharma Ltd

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Indications & Clinical Uses

Levobupivacaine is employed in regional anesthesia to block nerve conduction during surgical and obstetric procedures.

  • Surgical anesthesia: provides long‑lasting numbness for operative sites
  • Obstetric analgesia: enables epidural pain relief during labor
  • Post‑operative pain control: allows infiltration for postoperative analgesia
  • Dental procedures: facilitates local infiltration anesthesia for oral surgery
  • Peripheral nerve block: offers anesthesia for limb surgeries

How It Works

  • Levobupivacaine reversibly blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. By stabilizing the neuronal membrane, it inhibits nerve impulse transmission in the targeted area, resulting in loss of sensation and analgesia. The drug’s high protein binding and intrinsic vasoconstrictive properties prolong its anesthetic effect while limiting systemic absorption.

Side Effects

Common Side Effects

  • Hypotension: transient drop in blood pressure
  • Bradycardia: slowed heart rate
  • Nausea: mild to moderate nausea
  • Dizziness: occasional light‑headedness

Serious or Rare Side Effects

  • Cardiac arrest: rare but life‑threatening arrhythmia
  • Seizures: central nervous system toxicity
  • Methemoglobinemia: rare blood disorder causing reduced oxygen delivery
  • Allergic reaction: anaphylaxis or severe hypersensitivity

Precautions & Warnings

Levobupivacaine should be used with careful clinical assessment and monitoring.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics
  • Cardiovascular monitoring: observe heart rate and blood pressure during administration
  • Dose calculation: adjust for patient weight and comorbidities
  • Concurrent CNS depressants: use caution with other agents that may lower seizure threshold
  • Pregnancy and lactation: consider risk‑benefit, use only if clearly needed
  • Store at ambient temperature: keep in original container, protect from light and moisture

Avoid Interactions

Levobupivacaine may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

  • Class I anti‑arrhythmics (e.g., quinidine): may increase cardiotoxicity
  • Beta‑blockers: can potentiate bradycardia
  • Other local anesthetics: additive toxicity risk

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma levels
  • Diuretics: may affect plasma protein binding
  • Magnesium sulfate: may enhance neuromuscular blockade

Frequently Asked Questions

Levobupivacaine Altan Pharma is a sterile solution of the local anesthetic levobupivacaine. It is used to provide regional anesthesia for surgical procedures, obstetric epidural analgesia, and postoperative pain control through infiltration or nerve block techniques.

Levobupivacaine works by reversibly blocking voltage‑gated sodium channels on nerve membranes. This inhibition prevents the initiation and propagation of action potentials, resulting in loss of sensation and analgesia in the area where the drug is administered.

The dose of levobupivacaine is determined by the prescribing clinician based on the type of procedure, route of administration, patient weight, and clinical condition. Only a qualified health professional should set the appropriate dosage.

Safety data for levobupivacaine in pregnancy and lactation are limited. It should be used only when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Levobupivacaine is the S‑enantiomer of bupivacaine and generally offers a similar duration of anesthesia with a lower risk of cardiotoxicity and central nervous system toxicity. Both are amide‑type local anesthetics, but levobupivacaine is often preferred when a safer cardiac profile is desired.

Levobupivacaine should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed container. Avoid freezing and ensure that the solution is not used beyond its expiration date.

Levobupivacaine is administered by a qualified health professional via epidural, intrathecal, or local infiltration injection. The exact technique and volume depend on the intended block, the surgical site, and the patient’s clinical status.

Serious risks include cardiovascular collapse such as cardiac arrest, severe hypotension, bradycardia, central nervous system toxicity leading to seizures, and rare allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these occur.

Levobupivacaine should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, those with severe cardiac conduction disorders, uncontrolled epilepsy, or in situations where a safer alternative is clinically indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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