Product image of Levobupivacaïne Fresenius Kabi (Levobupivacaine Hydrochloride) supplied by GNH India

Levobupivacaïne Fresenius Kabi

Active Ingredient:
Levobupivacaine Hydrochloride
Origin:
EU

Levobupivacaïne Fresenius Kabi (Levobupivacaine Hydrochloride)

Levobupivacaine, the active ingredient in Levobupivacaïne Fresenius Kabi, is a local anesthetic (amide) presented as a sterile solution for epidural use. It provides regional anesthesia for surgical procedures, labor, and postoperative pain management.

GNH India supplies Levobupivacaïne Fresenius Kabi as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Nederland B.V.

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Indications & Clinical Uses

Levobupivacaine is used in the regional anesthesia pathway to provide analgesia for several clinical situations.

  • Surgical anesthesia: produces loss of sensation during operative procedures.
  • Labor analgesia: offers effective pain relief for women in childbirth.
  • Postoperative analgesia: extends pain control after surgery.

How It Works

  • Levobupivacaine reversibly blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. By stabilising the neuronal membrane, it inhibits the transmission of pain signals from the site of injection to the central nervous system, resulting in localized loss of sensation without affecting consciousness.

Side Effects

Levobupivacaine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypotension: drop in blood pressure after epidural administration.
  • Bradycardia: slower than normal heart rate.
  • Nausea: feeling of sickness or urge to vomit.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Cardiac arrest: sudden loss of heart function.
  • Seizures: uncontrolled electrical activity in the brain.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When using Levobupivacaine, clinicians should observe several safety measures.

  • Dose titration: adjust the amount based on patient response and procedure length.
  • Cardiovascular monitoring: continuously observe heart rate and blood pressure during administration.
  • Avoid intravascular injection: aspirate before injecting to confirm correct placement.
  • Use with caution in hepatic impairment: reduced metabolism may increase drug exposure.
  • Pregnancy: limited data; use only when benefit outweighs potential risk.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Levobupivacaine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): may increase cardiotoxicity.
  • Beta‑blockers: additive bradycardia and hypotension.
  • General anesthetics (e.g., propofol): may potentiate central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Opioids: may enhance respiratory depression.
  • NSAIDs: may increase bleeding risk when combined with regional techniques.
  • Magnesium sulfate: may potentiate neuromuscular blockade.

Frequently Asked Questions

Levobupivacaïne Fresenius Kabi contains levobupivacaine, a local anesthetic used to provide regional anesthesia for surgical procedures, labor analgesia, and postoperative pain control. It is administered via the epidural route to achieve targeted loss of sensation while the patient remains conscious.

Levobupivacaine works by reversibly blocking voltage‑gated sodium channels on nerve fibers. This inhibition prevents the initiation and propagation of action potentials, thereby stopping pain signals from reaching the brain and producing a localized anesthetic effect.

The specific dose of Levobupivacaïne Fresenius Kabi is determined by the prescribing clinician based on the type of procedure, patient characteristics, and desired depth of anesthesia. Healthcare professionals follow established guidelines and adjust the dose to achieve safe and effective analgesia.

Safety data for levobupivacaine in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levobupivacaine is the S‑enantiomer of bupivacaine and generally offers a similar duration of anesthesia with a lower risk of cardiotoxicity and central nervous system toxicity. Both agents provide effective regional blocks, but levobupivacaine is often preferred when a safer cardiac profile is desired.

The product should be stored below 25 °C, in its original packaging, protected from light and moisture. It must be kept out of reach of children and handled using aseptic technique to maintain sterility before epidural administration.

Levobupivacaïne is administered by a trained clinician via the epidural route. The solution is injected into the epidural space using a sterile technique, often after confirming correct needle placement by aspiration and, when appropriate, using imaging guidance.

Serious risks include cardiac arrest, severe hypotension, seizures, and allergic reactions such as anaphylaxis. These events are rare but require immediate medical intervention, continuous monitoring, and readiness to manage cardiovascular or respiratory complications.

Patients with known hypersensitivity to levobupivacaine or other amide‑type local anesthetics, those with significant cardiac conduction disorders, or individuals with uncontrolled severe hepatic impairment should avoid this medication. The decision should be individualized by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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