Product image of Levocabastin (Levocabastine Hydrochloride) supplied by GNH India

Levocabastin

Active Ingredient:
Levocabastine Hydrochloride
Origin:
EU

Levocabastin (Levocabastine Hydrochloride)

Levocabastine, the active ingredient in Levocabastine, is a H1 receptor antagonist presented as an ophthalmic solution for ocular use. It is indicated for allergic conjunctivitis, seasonal allergic eye disease, and ocular itching due to allergy, and is available over‑the‑counter in the EU.

GNH India supplies Levocabastine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Dermapharm Ag

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Indications & Clinical Uses

Levocabastine is an ocular antihistamine used to manage allergic eye conditions.

  • Allergic conjunctivitis: reduces redness, itching and swelling of the conjunctiva.
  • Seasonal allergic eye disease: alleviates symptoms triggered by pollen or seasonal allergens.
  • Ocular itching due to allergy: provides rapid relief of itch and discomfort.

How It Works

  • Levocabastine acts as a selective histamine H1‑receptor antagonist. By binding to H1 receptors on conjunctival blood vessels and mast cells, it blocks histamine‑induced vasodilation and increased vascular permeability, thereby preventing the inflammatory cascade that leads to redness, edema and itching in the eye.

Side Effects

Levocabastine may cause ocular or systemic adverse reactions, although most are mild and transient.

Common Side Effects

  • Burning sensation: mild transient eye burning after instillation.
  • Stinging: brief stinging feeling in the eye.
  • Redness: mild conjunctival redness.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Allergic contact dermatitis: localized skin reaction around the eye.
  • Corneal ulceration: rare ulcer formation on the cornea.
  • Anaphylaxis: extremely rare systemic allergic reaction.

Precautions & Warnings

When using Levocabastine ophthalmic solution, consider the following precautions to ensure safe and effective use.

  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown; weigh benefits against potential risks.
  • Contact lenses: remove lenses before instillation and wait before reinserting.
  • Concomitant eye medications: avoid simultaneous use; administer other drops at least 5 minutes apart.
  • Allergic history: assess for known hypersensitivity to antihistamines or formulation components.
  • Store at room temperature: keep below 25 °C, protect from light and moisture in the original container.

Avoid Interactions

Levocabastine may interact with other ophthalmic agents or systemic drugs.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): potential additive antihistaminic effects may increase ocular irritation.
  • Other H1‑antagonist eye drops: combined use can enhance local side effects.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may affect tear film stability.
  • Topical corticosteroids: monitor for increased intra‑ocular pressure.
  • Systemic antihistamines: may increase overall antihistaminic burden.

Frequently Asked Questions

Levocabastine is an ophthalmic antihistamine indicated for the relief of symptoms associated with allergic conjunctivitis, seasonal allergic eye disease, and ocular itching caused by allergy. It helps reduce redness, itching, and swelling in the eyes by counteracting the effects of histamine released during allergic reactions.

Levocabastine works by selectively blocking histamine H1 receptors on the cells of the conjunctiva and blood vessels in the eye. This inhibition prevents histamine‑induced vasodilation and increased vascular permeability, thereby reducing the inflammatory response that causes redness, edema, and itching in allergic eye conditions.

The appropriate dose of Levocabastine ophthalmic solution is determined by a qualified healthcare professional based on the patient’s age, severity of symptoms, and clinical judgment. Typically, one or two drops are instilled into the affected eye(s) as needed, but the exact regimen should follow the prescriber’s instructions.

Safety data for Levocabastine in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Levocabastine with their healthcare provider.

To order Levocabastine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Levocabastine is a selective H1‑receptor antagonist with a rapid onset of action and a favorable safety profile. Compared with some older antihistamine eye drops, it often provides quicker symptom relief and is less likely to cause prolonged stinging. However, clinical choice depends on individual patient response, tolerability, and prescriber preference.

Levocabastine ophthalmic solution should be stored at room temperature, preferably below 25 °C, in its original container. Protect the bottle from direct sunlight, moisture and extreme temperatures. Keep the cap tightly closed when not in use and discard any solution that appears discolored or contaminated.

Levocabastine is administered as an eye drop. The patient should wash their hands, tilt the head back, and gently pull down the lower eyelid to create a small pocket. One or two drops are placed into the affected eye(s). The eye should be closed gently for a few seconds to allow absorption, and contact lenses should be removed before use.

While most adverse reactions are mild, serious risks include allergic contact dermatitis around the eye, corneal ulceration, and rare systemic anaphylactic reactions. If a patient experiences persistent eye irritation, vision changes, severe swelling, or signs of an allergic reaction such as rash or difficulty breathing, they should seek immediate medical attention.

Levocabastine should not be used by individuals with a known hypersensitivity to levocabastine, other antihistamines, or any component of the ophthalmic formulation. Patients with a history of severe ocular surface disease or corneal ulceration should consult a healthcare professional before use. Children under the age recommended by the prescriber should also avoid the medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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