Product image of Levocar Retard (Carbidopa, Levodopa) supplied by GNH India

Levocar Retard

Active Ingredient:
Carbidopa, Levodopa
Origin:
EU

Levocar Retard (Carbidopa, Levodopa)

Carbidopa/Levodopa, the active ingredient in Levocar Retard, is a Levodopa/Carbidopa combination presented as an oral tablet for oral use. It treats Parkinson's disease and Parkinsonian syndrome in adult patients.
GNH India supplies Levocar Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Gmbh

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Indications & Clinical Uses

  • Levocar Retard, a Levodopa/Carbidopa combination, is employed in the management of movement disorders within the Parkinsonian disease spectrum.
  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity and tremor.
  • Parkinsonian syndrome: alleviates motor deficits associated with secondary parkinsonism.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, replenishing central dopaminergic activity. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, reducing peripheral levodopa conversion, thereby increasing the amount of levodopa that reaches the brain and minimizing peripheral side effects.

Side Effects

Levocar Retard may cause a range of adverse reactions.

Common Side Effects

  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Headache
  • Orthostatic hypotension
  • Insomnia
  • Constipation

Serious or Rare Side Effects

  • Dyskinesia (involuntary movements)
  • Hallucinations or psychosis
  • Severe hypotension or syncope
  • Neuroleptic malignant syndrome
  • Cardiac arrhythmias
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several precautionary measures.
  • Dose titration: start low and increase gradually under medical supervision.
  • Cardiovascular monitoring: watch for orthostatic hypotension.
  • Psychiatric assessment: monitor for hallucinations or confusion.
  • Renal/hepatic impairment: adjust dose if needed.
  • Drug interactions: review concomitant medications for MAO‑B inhibitors.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levocar Retard can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): may reduce antiparkinson efficacy.
  • High‑dose pyridoxine (vitamin B6): may diminish levodopa absorption.

Moderate Interactions (Monitor Closely)

  • COMT inhibitors: may increase levodopa plasma levels.
  • Iron or calcium supplements: may decrease levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensives: may exacerbate orthostatic hypotension.

Frequently Asked Questions

Levocar Retard is prescribed to manage the motor symptoms of Parkinson's disease and Parkinsonian syndrome. It helps reduce stiffness, tremor, and slowness of movement by restoring dopamine activity in the brain, thereby improving patients' functional abilities and quality of life.

Levodopa is a precursor that the brain converts into dopamine, compensating for the loss of dopaminergic neurons in Parkinsonian disorders. Carbidopa blocks the enzyme aromatic L‑amino acid decarboxylase outside the brain, preventing premature conversion of levodopa and allowing more of the drug to reach the central nervous system.

The appropriate dose of Levocar Retard is individualized by the prescribing clinician based on disease severity, patient response, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control while minimizing side effects.

Safety data for Levocar Retard in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should consult their physician before using this medication.

To request Levocar Retard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocar Retard combines levodopa with carbidopa, offering a higher proportion of levodopa to reach the brain compared with levodopa alone. Compared with dopamine agonists, it generally provides stronger symptomatic relief but may have a higher risk of motor complications such as dyskinesia. Choice of therapy depends on individual patient factors.

Levocar Retard should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Levocar Retard is taken orally, usually with a small amount of food to reduce gastrointestinal irritation. Tablets should be swallowed whole with water and not crushed or chewed unless specifically directed by a healthcare professional.

Serious risks include the development of dyskinesia (involuntary movements), hallucinations or psychosis, severe orthostatic hypotension, and rare but life‑threatening reactions such as neuroleptic malignant syndrome or severe allergic responses. Patients should seek immediate medical attention if any of these occur.

Levocar Retard is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, or any excipients in the formulation. It should also be avoided in individuals taking non‑selective MAO inhibitors or those with a history of malignant neuroleptic syndrome. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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