Product image of Nefrocarnit® (Levocarnitine) supplied by GNH India

Nefrocarnit®

Active Ingredient:
Levocarnitine
Origin:
EU

Nefrocarnit® (Levocarnitine)

Levocarnitine, the active ingredient in Nefrocarnit®, is a carnitine supplement presented as an oral tablet for oral use. It is indicated for primary and secondary carnitine deficiency and helps support fatty‑acid metabolism in various metabolic disorders.

GNH India supplies Nefrocarnit® as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is marketed in the European Union as an over‑the‑counter nutritional supplement. All shipments comply with EU GMP standards and are traceable through batch certification. This ensures consistent product quality for patients and healthcare providers.

Manufacturer / TM Owner

Medice Arzneimittel Pütter Gmbh & Co. Kg

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Indications & Clinical Uses

Nefrocarnit® (levocarnitine) is used to address disorders of carnitine metabolism and related fatty‑acid oxidation pathways.

  • Primary carnitine deficiency: restores intracellular carnitine levels to improve energy production.
  • Secondary carnitine deficiency: replenishes carnitine lost due to renal loss, dialysis or certain medications, aiding metabolic stability.
  • Metabolic disorders affecting fatty‑acid oxidation: supports β‑oxidation, helping reduce accumulation of fatty acids and associated symptoms.

How It Works

  • Levocarnitine is the biologically active L‑enantiomer of carnitine. It is taken up by cells via the organic cation transporter OCTN2 and binds to the inner mitochondrial membrane, where it forms acetyl‑carnitine and transports long‑chain fatty acids across the membrane into the mitochondrial matrix. This enables β‑oxidation and subsequent ATP generation, thereby supporting cellular energy metabolism.

Side Effects

Oral levocarnitine is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes, usually transient.
  • Abdominal cramps: discomfort in the lower abdomen.
  • Diarrhea: loose stools that resolve with continued use.
  • Fish‑like body odor: due to metabolite excretion.
  • Headache: mild tension‑type headaches.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Stevens‑Johnson syndrome: rare skin eruption with mucosal involvement.
  • Hyperkalemia: elevated serum potassium levels, especially in renal impairment.
  • Severe rash: extensive erythema or urticaria.
  • Hepatotoxicity: abnormal liver enzymes in susceptible individuals.

Precautions & Warnings

Before initiating levocarnitine therapy, consider the following precautions.

  • Renal impairment: monitor serum carnitine levels and adjust dose if needed.
  • Thyroid disorders: assess thyroid function before initiating therapy.
  • Pregnancy and lactation: use only if the expected benefit outweighs potential risk.
  • Concomitant valproate therapy: watch for increased risk of hepatotoxicity.
  • Drug interactions: review patient medication list for potential interactions.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocarnitine may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Valproic acid: may increase risk of hepatotoxicity.
  • Cisplatin: may exacerbate nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Carbapenem antibiotics: may reduce carnitine absorption.
  • Hemodialysis: may remove levocarnitine, requiring supplemental dosing.
  • Thyroid hormone therapy: may alter carnitine metabolism.

Frequently Asked Questions

Nefrocarnit® contains levocarnitine and is used to treat primary and secondary carnitine deficiency as well as to support fatty‑acid metabolism in metabolic disorders where energy production from fatty acids is impaired.

Levocarnitine transports long‑chain fatty acids into mitochondria by forming a complex with them, allowing β‑oxidation to proceed. This process generates ATP, supporting cellular energy especially in tissues that rely heavily on fatty‑acid oxidation.

The appropriate dose of Nefrocarnit® is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and laboratory results. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for levocarnitine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nefrocarnit® provides levocarnitine, the biologically active L‑enantiomer, which is the form most efficiently taken up by cells. Some alternatives contain the racemic mixture (D‑ and L‑carnitine) that may be less effective for metabolic support.

Store Nefrocarnit® at ambient temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not refrigerate or freeze the product.

Nefrocarnit® is taken orally, usually with water. The tablet should be swallowed whole and not chewed, unless the prescriber advises otherwise.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and hyperkalemia, particularly in patients with renal impairment. Immediate medical attention is required if any of these symptoms occur.

Patients with known hypersensitivity to levocarnitine or any excipients, those with severe renal failure without appropriate monitoring, and individuals taking contraindicated medications such as valproic acid or cisplatin should avoid using Nefrocarnit® unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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