Product image of Levocetirizin Actavis (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizin Actavis

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizin Actavis (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizin Actavis, is an antihistamine presented as an oral tablet for systemic use. It reduces symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children as directed by a healthcare professional.

GNH India supplies Levocetirizin Actavis as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide from its EU‑sourced manufacturing network. Our distribution ensures consistent quality and regulatory adherence across global markets.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

  • Levocetirizine is an antihistamine that targets histamine‑mediated allergic conditions.
  • Allergic rhinitis (seasonal or perennial): alleviates nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: decreases the frequency and severity of hives and associated itching.
  • Allergic conjunctivitis: helps reduce eye itching and redness caused by histamine release.

How It Works

  • Levocetirizine acts as a selective antagonist of peripheral histamine H1 receptors. By binding to these receptors on mast cells, basophils and other target tissues, it blocks the action of endogenous histamine released during allergic reactions, thereby preventing the cascade of vascular permeability, nerve stimulation and smooth‑muscle contraction that produce typical allergy symptoms.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation
  • Fatigue or feeling of tiredness
  • Dry mouth
  • Headache
  • Nausea
  • Abdominal discomfort

Serious or Rare Side Effects

  • Angioedema or swelling of the face, lips or tongue
  • Anaphylactic reactions
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Tachycardia or irregular heartbeat
  • Hepatic dysfunction
  • Blood dyscrasias including neutropenia or thrombocytopenia

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Pregnancy: consult a healthcare provider to assess risk‑benefit.
  • Breastfeeding: evaluate potential exposure to the infant.
  • Renal impairment: dose adjustment may be required in reduced kidney function.
  • Elderly patients: monitor for increased sedation or confusion.
  • Drug interactions: review concomitant medications for possible additive effects.
  • Store at ambient temperature: keep below 25 °C, retain in the original packaging, and protect from moisture.

Avoid Interactions

Levocetirizine may interact with several medicines; categorize them as follows.

Major Interactions (Avoid)

  • Alcohol: can enhance sedation and drowsiness.
  • Central nervous system depressants (e.g., benzodiazepines, opioids): additive sedative effect.
  • Antifungal ketoconazole: may increase plasma concentrations of levocetirizine.

Moderate Interactions (Monitor Closely)

  • Ritonavir: potential increase in exposure.
  • Theophylline: possible reduction in clearance.
  • Macrolide antibiotics (e.g., erythromycin): may affect metabolism and plasma levels.

Frequently Asked Questions

Levocetirizin Actavis contains levocetirizine, an antihistamine indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria. It helps reduce nasal congestion, sneezing, itching, and the formation of hives, providing symptomatic control in patients with these allergic conditions.

Levocetirizine selectively blocks peripheral histamine H1 receptors, preventing histamine released during allergic reactions from binding to these sites. This inhibition reduces vascular permeability, nerve stimulation, and smooth‑muscle contraction, thereby alleviating the typical signs of allergy such as itching, swelling, and nasal discharge.

The appropriate dose of Levocetirizin Actavis is determined by a qualified prescriber based on the patient’s age, clinical condition, renal function and other individual factors. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential adverse effects.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Pregnant or nursing women should discuss the medication with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it provides more selective H1‑receptor blockade and fewer anticholinergic side effects, making it a preferred option for many patients requiring daily allergy control.

Store the tablets at ambient temperature, preferably below 25 °C, in their original blister pack or container. Protect them from moisture, direct sunlight and excessive heat. Keep the product out of reach of children and do not use it after the expiry date indicated on the packaging.

Levocetirizin Actavis is administered orally, typically as a tablet swallowed whole with water. It can be taken with or without food, according to the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and avoid crushing or chewing the tablet unless directed otherwise.

While generally well tolerated, serious adverse events can include angioedema, anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome, tachycardia, hepatic dysfunction and hematologic abnormalities. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, difficulty breathing, or unexplained fatigue.

Levocetirizin Actavis should be avoided in individuals with known hypersensitivity to levocetirizine, other piperazine antihistamines, or any of the product’s excipients. Caution is also advised for patients with severe renal impairment, uncontrolled asthma, or those taking medications that may cause significant drug‑drug interactions without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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