Levocetirizin Adgc (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride acts on histamine‑mediated allergic pathways and is indicated for the following conditions:

• Allergic rhinitis: reduces nasal congestion, sneezing and itching.
• Chronic idiopathic urticaria: alleviates hives and associated itching.
• Seasonal allergic conjunctivitis: eases eye redness and itching.

• Levocetirizine Dihydrochloride selectively blocks peripheral H1‑histamine receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug reduces the typical allergic symptoms without crossing the blood‑brain barrier in significant amounts, limiting central nervous system effects.

Levocetirizin Adgc may cause a range of adverse reactions. Most are mild and reversible.

Common Side Effects

• Drowsiness: mild sleepiness, especially after the first dose.
• Headache: transient tension‑type headache.
• Dry mouth: reduced salivation.
• Fatigue: general lack of energy.
• Nausea: mild stomach upset.
• Altered taste: metallic or bitter sensation.

Serious or Rare Side Effects

• Angioedema: swelling of face, lips or tongue.
• Anaphylaxis: severe allergic reaction requiring emergency care.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Hepatic dysfunction: abnormal liver enzymes.
• Blood dyscrasias: neutropenia or thrombocytopenia.
• Cardiac arrhythmia: rare conduction disturbances.

Before using Levocetirizin Adgc, consider the following safety measures:

• Pregnancy: consult a healthcare professional before use.
• Renal impairment: dose may need adjustment in severe cases.
• Elderly patients: monitor for increased sedation.
• Alcohol consumption: avoid or limit as it may enhance drowsiness.
• Driving or operating machinery: exercise caution if drowsy.
• Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Levocetirizin Adgc can interact with several medicines. Review the categories below.

Major Interactions (Avoid)

• Alcohol: additive sedative effect.
• CNS depressants (e.g., benzodiazepines): may cause excessive drowsiness.
• Ritonavir: can increase levocetirizine plasma concentrations.

Moderate Interactions (Monitor Closely)

• Theophylline: levocetirizine may raise theophylline levels.
• Ketoconazole: may elevate levocetirizine exposure.
• Other antihistamines: combined use can increase anticholinergic burden.