Product image of Levocetirizin Al (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizin Al

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizin Al (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Levocetirizin Al, is a second‑generation antihistamine presented as an oral dosage form for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and children.
GNH India supplies Levocetirizin Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Levocetirizin Al is a selective H1‑receptor antagonist used to manage allergic conditions.

  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and rhinorrhoea.
  • Chronic idiopathic urticaria: reduces the frequency and severity of hives and associated itching.
  • Seasonal allergic rhinitis: controls episodic nasal and ocular symptoms triggered by pollen or other seasonal allergens.

How It Works

  • Levocetirizine dihydrochloride binds selectively to peripheral H1‑histamine receptors, preventing histamine from activating these receptors. By blocking this pathway, it inhibits the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic signs of an allergic response such as itching, swelling, and mucus production.

Side Effects

Adverse reactions may occur with levocetirizine use.

Common Side Effects

  • Drowsiness: mild to moderate sedation, especially at treatment initiation.
  • Headache: transient, often resolves without intervention.
  • Dry mouth: reduced salivation causing mild discomfort.
  • Fatigue: general feeling of tiredness.
  • Altered taste: temporary metallic or bitter sensation.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue requiring urgent care.
  • Severe rash or Stevens‑Johnson syndrome: extensive skin involvement.
  • Anaphylaxis: rapid onset of systemic allergic reaction.
  • Thrombocytopenia: unusually low platelet count.
  • Hepatic injury: elevated liver enzymes or jaundice.

Precautions & Warnings

Before prescribing Levocetirizin Al, consider the following safety measures.

  • Renal function assessment: dose may need adjustment in impaired clearance.
  • Elderly patients: monitor for increased sedation or confusion.
  • Driving and machinery: avoid operating until individual response is known.
  • Hypersensitivity history: discontinue if rash or swelling develops.
  • Concomitant CNS depressants: use with caution due to additive drowsiness.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizin Al can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other H1 antihistamines: additive antihistaminic effect may increase sedation.
  • Alcohol or sedative agents: heightened drowsiness and impaired psychomotor performance.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise plasma levocetirizine levels.
  • CYP1A2 inducers (e.g., theophylline, smoking): may reduce drug exposure.
  • Anticholinergic drugs: combined dry‑mouth effect may be more pronounced.

Frequently Asked Questions

Levocetirizin Al is indicated for the relief of symptoms associated with allergic rhinitis, including sneezing, nasal congestion, and itching, as well as for the management of chronic idiopathic urticaria, where it helps reduce the occurrence of hives and related itching.

Levocetirizine dihydrochloride selectively blocks peripheral H1‑histamine receptors, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation. This inhibition reduces the typical allergic manifestations such as itching, swelling, and mucus production.

The appropriate dose of Levocetirizin Al is determined by a qualified healthcare professional based on the patient’s age, weight, renal function, and clinical response. Prescribers set the regimen according to current clinical guidelines and individual patient needs.

Safety data for levocetirizine during pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks and consider alternative therapies when appropriate. Pregnant or nursing patients should discuss use with their physician.

To request Levocetirizin Al, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levocetirizin Al is a second‑generation H1‑receptor antagonist, offering effective allergy relief with a lower incidence of sedation compared with first‑generation antihistamines. Its rapid onset and once‑daily dosing make it convenient, while its selectivity reduces many central nervous system side effects seen with older agents.

Levocetirizin Al should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency throughout its shelf life.

Levocetirizin Al is taken orally, usually as a tablet or oral solution, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether to swallow the dose whole or dissolve it, if a liquid formulation is provided.

Although rare, serious adverse reactions can include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, thrombocytopenia, and significant liver enzyme elevations. Any signs of swelling, rash, or systemic allergic response require immediate medical attention.

Levocetirizin Al is contraindicated in individuals with known hypersensitivity to levocetirizine, cetirizine, or any excipients in the formulation. Patients with severe renal impairment may need alternative therapy or dose adjustment, and those taking multiple CNS depressants should be evaluated carefully.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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