Levocetirizin Bei Allergien Hexal (Levocetirizine Dihydrochloride)

Levocetirizine is indicated for allergic conditions that involve histamine‑mediated inflammation, providing symptom control in both seasonal and perennial forms.

• Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
• Chronic urticaria: alleviates hives and associated itching, improving daily comfort.
• Allergic conjunctivitis: relieves eye itching, redness and tearing caused by allergens.
• Allergic skin reactions: helps control itching and rash caused by contact allergens.
• Hay fever: mitigates sneezing, nasal itching and runny nose during pollen exposure.

• Levocetirizine acts as a highly selective antagonist of peripheral H1 histamine receptors. By blocking these receptors on mast cells, basophils and sensory nerves, it prevents histamine‑induced vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic symptoms of allergic inflammation without significant central nervous system penetration.

Levocetirine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Drowsiness: mild sedation, especially when treatment is initiated.
• Headache: transient, usually resolves without intervention.
• Dry mouth: reduced salivation leading to mild discomfort.
• Fatigue: feeling of tiredness that may lessen with continued use.

Serious or Rare Side Effects

• Angioedema: swelling of face, lips, tongue or throat requiring urgent care.
• Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylactic reaction: sudden severe allergic response that can be life‑threatening.

Before initiating therapy, consider the following precautions:

• Pregnancy: consult a healthcare professional to weigh potential benefits against risks.
• Breastfeeding: assess the need for treatment and monitor the infant for possible effects.
• Renal impairment: dose adjustment may be required in patients with reduced kidney function.
• Elderly patients: monitor for increased sedation or dizziness.
• Driving or operating machinery: exercise caution if drowsiness occurs.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Levocetirizine can interact with several medicines; awareness helps avoid adverse outcomes.

Major Interactions (Avoid)

• Ketoconazole: may increase levocetirizine plasma concentrations.
• Ritonavir: can raise levocetirizine levels, enhancing side effects.
• Theophylline: may potentiate theophylline toxicity.

Moderate Interactions (Monitor Closely)

• Alcohol: additive sedation and impaired alertness.
• Sedative antihistamines: increased risk of drowsiness.
• Central nervous system depressants: monitor for enhanced sedation or respiratory depression.