Product image of Levocetirizin Krka (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizin Krka

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizin Krka (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizin Krka, is a second‑generation antihistamine presented as a tablet for oral use. It alleviates histamine‑mediated symptoms such as sneezing, nasal congestion, itching and hives in patients with allergic rhinitis or chronic idiopathic urticaria.

GNH India supplies Levocetirizin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for importers. Its global distribution network ensures reliable delivery to diverse healthcare settings.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levocetirizine Dihydrochloride is used to manage allergic conditions by blocking peripheral H1 receptors.

  • Allergic rhinitis (seasonal or perennial): reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: decreases frequency and severity of hives and associated itching.
  • Allergic conjunctivitis: alleviates eye itching, redness and watery discharge.

How It Works

  • Levocetirizine Dihydrochloride selectively binds to peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor interaction, the drug reduces the classic signs of allergic inflammation without readily crossing the blood‑brain barrier, thereby limiting central nervous system effects.

Side Effects

Levocetirizin Krka is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Drowsiness: mild to moderate sleepiness, especially at treatment initiation.
  • Headache: transient tension‑type headache.
  • Dry mouth: reduced salivation causing mild discomfort.
  • Fatigue: feeling of reduced energy.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring urgent care.
  • Severe skin rash (e.g., Stevens‑Johnson syndrome): extensive blistering and detachment of skin.
  • Anaphylactic reaction: sudden systemic hypersensitivity with respiratory compromise.

Precautions & Warnings

Levocetirizin Krka should be used with awareness of specific safety considerations.

  • Pregnancy: consult a healthcare professional as safety data are limited.
  • Breastfeeding: caution advised; the drug may be excreted in breast milk.
  • Renal impairment: use with caution; dose adjustment may be required in severe dysfunction.
  • Elderly patients: monitor for increased sedation or dizziness.
  • Avoid alcohol: concurrent intake may potentiate drowsiness.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Levocetirizin Krka may interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise levocetirizine plasma concentrations.
  • Alcohol or other central nervous system depressants: may enhance sedative effects.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may increase dry‑mouth sensation.
  • Theophylline: may reduce antihistamine efficacy.
  • Ritonavir: may modestly increase levocetirizine levels, requiring observation.

Frequently Asked Questions

Levocetirizin Krka is indicated for the symptomatic relief of allergic rhinitis, including both seasonal and perennial forms, and for chronic idiopathic urticaria. In these conditions it helps reduce nasal congestion, sneezing, itching, and the frequency of hives, providing patients with improved comfort during allergic episodes.

Levocetirizine Dihydrochloride works by selectively blocking peripheral H1 histamine receptors. This inhibition prevents histamine from binding to its receptors on blood vessels and sensory nerves, thereby reducing vasodilation, increased permeability, and nerve stimulation that cause typical allergy symptoms such as itching, swelling, and nasal discharge.

The appropriate dose of Levocetirizin Krka is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function, and severity of symptoms. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for levocetirizine during pregnancy are limited, so pregnant women should only use the product if the potential benefit outweighs any risk and after consulting their physician. While it is excreted in breast milk in small amounts, nursing mothers should discuss use with a healthcare provider to assess safety for the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levocetirizin Krka is a second‑generation H1 antagonist, offering effective allergy relief with a lower propensity for sedation compared with first‑generation antihistamines such as diphenhydramine. Compared with other second‑generation agents like cetirizine, it provides similar efficacy but may have a slightly faster onset and reduced central nervous system penetration.

Store Levocetirizin Krka at ambient temperature below 25 °C. Keep the tablets in their original blister pack, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Levocetirizin Krka is taken orally, usually with a glass of water. The tablet should be swallowed whole and can be taken with or without food, according to the prescriber’s guidance. Patients should avoid crushing or chewing the tablet unless specifically instructed.

The most serious adverse reactions, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Any signs of swelling of the face, lips, tongue, or difficulty breathing require immediate medical attention.

Levocetirizin Krka should be avoided in individuals with known hypersensitivity to levocetirizine or any of the excipients in the tablet. Caution is also advised for patients with severe renal impairment, pregnant or nursing women without medical supervision, and those taking interacting medications that could increase sedation or drug levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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