Product image of Levocetirizin + Pharma (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizin + Pharma

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizin + Pharma (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizin + Pharma, is a second‑generation antihistamine presented as an oral tablet for oral use. It selectively blocks peripheral H1 receptors, reducing the effects of histamine. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents, providing relief from nasal congestion, sneezing, itching and hives.
GNH India supplies Levocetirizin + Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets.

Manufacturer / TM Owner

+pharma Arzneimittel Gmbh

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Indications & Clinical Uses

Levocetirizine is used to manage histamine‑mediated allergic conditions, primarily affecting the respiratory tract and skin.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and runny nose.
  • Chronic idiopathic urticaria: alleviates hives and itching, improving quality of life.
  • Histamine‑mediated allergic symptoms: provides overall relief of itching, swelling and redness associated with allergic reactions.

How It Works

  • Levocetirizine acts as a selective peripheral H1‑receptor antagonist. By binding to H1 receptors on mast cells, basophils and other target cells, it prevents histamine from triggering the cascade that leads to vasodilation, increased vascular permeability and sensory nerve activation. This inhibition reduces the typical signs of allergic reactions such as itching, swelling, and nasal congestion without readily crossing the blood‑brain barrier, thereby limiting central nervous system effects.

Side Effects

Levocetirizine may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Drowsiness: mild sedation or sleepiness, usually transient and not dose‑dependent.
  • Headache: transient cranial discomfort that often resolves without treatment.
  • Dry mouth: reduced salivary flow causing mild throat irritation.

Serious or Rare Side Effects

  • Anaphylaxis: severe, potentially life‑threatening allergic reaction requiring immediate emergency care.
  • Stevens‑Johnson syndrome: rare, serious skin disorder with blistering and mucosal involvement.
  • Thrombocytopenia: significant reduction in platelet count that may increase bleeding risk.

Precautions & Warnings

When prescribing Levocetirine, clinicians should observe several precautionary measures to ensure safe use.

  • Assess patient history: evaluate for hypersensitivity to levocetirizine or other antihistamines.
  • Monitor renal function: dose adjustment may be required in severe renal impairment.
  • Caution in the elderly: increased susceptibility to sedation and anticholinergic effects.
  • Avoid driving if drowsiness occurs: advise patients to refrain from operating machinery until they know how the drug affects them.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Levocetirizine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Ketoconazole or erythromycin: may increase levocetirizine plasma levels, raising risk of side effects.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation, should be avoided.

Moderate Interactions (Monitor Closely)

  • Theophylline: may reduce antihistamine effect, monitor symptom control.
  • Rifampicin: may lower levocetirine concentrations, consider dose adjustment.
  • Other antihistamines: combined use can increase anticholinergic burden, monitor for excessive sedation.

Frequently Asked Questions

Levocetirizin + Pharma is indicated for the treatment of allergic rhinitis, including seasonal and perennial forms, and for chronic idiopathic urticaria. In these conditions it helps to reduce nasal congestion, sneezing, itching and the appearance of hives, providing symptomatic relief for patients who experience histamine‑mediated allergic reactions.

Levocetirizine works by selectively binding to peripheral H1‑histamine receptors on mast cells, basophils and other target cells. This antagonism blocks histamine from activating the receptors, preventing the cascade that leads to vasodilation, increased vascular permeability and nerve stimulation. The result is a reduction in typical allergy signs such as itching, swelling and nasal discharge without significant central nervous system penetration.

The exact dose of Levocetirizin + Pharma is determined by the prescribing healthcare professional. The prescriber considers factors such as the patient’s age, weight, renal function, severity of symptoms and any concomitant medications before selecting the appropriate strength and dosing interval. Patients should follow the individualized instructions provided on the prescription label.

Safety data for levocetirizine during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers typically advise a careful risk‑benefit assessment and may recommend alternative therapies if safer options are available.

To order Levocetirizin + Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details—including any required cold‑chain handling—and assists with import documentation.

Levocetirizin + Pharma belongs to the second‑generation antihistamine class, offering similar efficacy to cetirizine but with a lower propensity for sedation due to its higher selectivity for peripheral H1 receptors. Compared with first‑generation antihistamines, it provides better tolerability and fewer anticholinergic effects, making it a preferred option for patients needing daytime allergy control.

Levocetirizin + Pharma should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. Do not refrigerate or freeze the product, as this may affect tablet integrity.

The medication is administered orally, usually as a whole tablet swallowed with a glass of water. It can be taken with or without food, and patients should avoid crushing or chewing the tablet unless specifically instructed by a healthcare professional. Consistent daily intake at the same time of day helps maintain stable symptom control.

The most serious risks associated with Levocetirizin + Pharma include rare but potentially life‑threatening reactions such as anaphylaxis, Stevens‑Johnson syndrome and severe thrombocytopenia. Patients should be instructed to seek immediate medical attention if they experience symptoms like difficulty breathing, widespread skin blistering, or unexplained bruising or bleeding.

Levocetirizin + Pharma should not be used by individuals with known hypersensitivity to levocetirizine or any of its excipients. Caution is also advised for patients with severe renal impairment, pregnant or breastfeeding women unless clearly indicated, and those taking medications that may cause significant drug interactions. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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