Levocetirizin Stada (Levocetirizine Dihydrochloride)

• Levocetirizin Stada is a second‑generation H1 antihistamine that acts on allergic pathways to alleviate symptoms.
• Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea caused by seasonal or perennial allergens.
• Chronic idiopathic urticaria: diminishes wheal formation and itching in patients with persistent hives.

• Levocetirizine is a selective antagonist of peripheral H1 histamine receptors. By binding to these receptors, it blocks the action of histamine released during allergic reactions, thereby preventing the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation that cause typical allergy symptoms.

Levocetirizin Stada may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

• Headache: mild to moderate pain often reported during early treatment.
• Somnolence: transient drowsiness, especially after the first doses.
• Dry mouth: reduced salivation leading to a feeling of oral dryness.
• Fatigue: general tiredness without loss of consciousness.
• Dizziness: light‑headed sensation that usually resolves with continued use.

Serious or Rare Side Effects

• Anaphylaxis: acute, life‑threatening allergic reaction requiring immediate medical attention.
• Angioedema: swelling of the face, lips, tongue or throat that may compromise airway.
• Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Cardiac arrhythmia: rare reports of irregular heart rhythm.
• Hepatic injury: uncommon elevation of liver enzymes.

• Before initiating therapy with Levocetirizin Stada, consider the following precautions.
• Pregnancy: consult a healthcare professional; safety data are limited.
• Renal impairment: dose adjustment may be necessary in patients with reduced kidney function.
• Elderly: monitor for increased sedation or confusion.
• Concomitant CNS depressants: may enhance drowsiness and impair coordination.
• Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Levocetirizin Stada can interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

• Potent CYP3A4 inhibitors: may raise levocetirizine plasma concentrations.
• Alcohol: additive central nervous system depression leading to excessive sedation.

Moderate Interactions (Monitor Closely)

• Other sedating antihistamines: may increase drowsiness.
• Ritonavir: can elevate levocetirizine exposure.
• Theophylline: may result in higher theophylline levels.
• Anticholinergic agents: could exacerbate dry‑mouth effects.