Product image of Levocetirizin Tad (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizin Tad

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizin Tad (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizin Tad, is a second‑generation H1‑antagonist presented as an oral formulation for oral use. It is indicated to relieve nasal and ocular symptoms of allergic rhinitis and to control hives and itching in chronic idiopathic urticaria for both adults and children.

GNH India supplies Levocetirizin Tad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export across multiple regions.

Manufacturer / TM Owner

Tad Pharma Gmbh

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Indications & Clinical Uses

Levocetirizine is a second‑generation antihistamine that reduces histamine‑mediated allergic responses.

  • Allergic rhinitis: alleviates sneezing, nasal congestion, itching and rhinorrhea.
  • Chronic idiopathic urticaria: reduces the frequency and severity of hives and associated itching.
  • Seasonal allergic rhinitis: controls symptoms triggered by pollen exposure.

How It Works

  • Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and activating the receptor cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this pathway, it diminishes the early and late-phase allergic inflammatory response without readily crossing the blood‑brain barrier, thereby limiting central sedation. The drug’s high affinity for the H1 site ensures prolonged receptor occupancy, providing 24‑hour symptom control after a single dose.

Side Effects

Levocetirizine may cause adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often transient.
  • Drowsiness: occasional sleepiness, especially at initiation.
  • Dry mouth: reduced salivation.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring urgent care.
  • Anaphylaxis: severe allergic reaction with respiratory compromise.
  • Stevens‑Johnson syndrome: rare skin eruption with blistering.

Precautions & Warnings

When prescribing Levocetirizine, consider the following precautions to ensure safe use.

  • Renal impairment: assess kidney function and adjust therapy if necessary.
  • Elderly patients: monitor for increased sedation or dizziness.
  • Pregnancy: use only if potential benefit justifies potential risk to the fetus.
  • Concomitant CNS depressants: may enhance drowsiness, advise caution with driving.
  • Alcohol consumption: can potentiate sedative effects, limit intake.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levocetirizine can interact with other medicines; awareness of major and moderate interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Ketoconazole: may increase levocetirizine plasma concentrations.
  • Ritonavir: can raise drug levels, enhancing side effects.
  • Theophylline: may potentiate theophylline toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive sedation, advise limited use.
  • Other antihistamines: risk of cumulative antihistaminic effects.
  • CNS depressants (e.g., benzodiazepines): monitor for excessive drowsiness.

Frequently Asked Questions

Levocetirizin Tad contains levocetirizine, which is indicated for the relief of symptoms associated with allergic rhinitis—including sneezing, nasal congestion, itching and watery eyes—as well as for the control of chronic idiopathic urticaria, helping to reduce the occurrence of hives and related itching.

Levocetirizine acts as a selective peripheral H1‑histamine receptor antagonist. By binding to these receptors, it blocks histamine from triggering the cascade that causes vasodilation, increased vascular permeability, and nerve stimulation, thereby diminishing the early and late phases of the allergic inflammatory response.

The appropriate dose of Levocetirizin Tad is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, renal function and any concomitant therapies. Dosage recommendations are provided in the product label, but the final regimen is set by the prescriber.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss the risks and benefits with their physician.

To order Levocetirizin Tad, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. The sales team will request trade or institutional credentials, then respond with pricing, availability, shipping details and any required import documentation.

Levocetirizin Tad is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation because of its higher selectivity for peripheral H1 receptors. Both drugs belong to the second‑generation antihistamine class, but levocetirizine may provide a more favorable side‑effect profile for some patients.

Levocetirizin Tad should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Levocetirizin Tad is taken orally, usually with a glass of water. It can be taken with or without food, according to the prescriber’s instructions. The tablet should be swallowed whole and not crushed or chewed unless specifically advised by a healthcare professional.

Serious adverse reactions, although rare, include angioedema, anaphylactic shock and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience swelling of the face or throat, difficulty breathing, or a widespread rash with blistering.

Levocetirizin Tad should be avoided in individuals with known hypersensitivity to levocetirizine or any of the excipients in the formulation. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking medications that may interact significantly with levocetirizine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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