Product image of Levocetirizina Aurobindo (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Aurobindo

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Aurobindo (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizina Aurobindo, is a second‑generation antihistamine presented as a oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and children. The medication works by blocking peripheral H1 receptors, thereby reducing the release of inflammatory mediators that cause sneezing, itching, and skin rash.

GNH India supplies Levocetirizina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company emphasizes quality assurance and regulatory compliance across EU markets.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Levocetirizine is a second‑generation antihistamine that alleviates histamine‑mediated allergic conditions.

  • Seasonal allergic rhinitis: reduces nasal congestion, sneezing and itching.
  • Perennial allergic rhinitis: improves nasal discharge and ocular symptoms.
  • Chronic idiopathic urticaria: lessens hives and associated itching.

How It Works

  • Levocetirizine selectively blocks peripheral histamine H1 receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug reduces the release of inflammatory mediators responsible for the symptoms of allergic rhinitis and urticaria, while minimally crossing the blood‑brain barrier, which limits central nervous system effects.

Side Effects

Levocetirizine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness
  • Headache
  • Dry mouth
  • Nausea

Serious or Rare Side Effects

  • Angioedema
  • Stevens‑Johnson syndrome
  • Anaphylactic reaction

Precautions & Warnings

Before prescribing levocetirizine, consider the following precautions to ensure safe use.

  • Pregnancy: consult a healthcare professional as safety data are limited.
  • Breastfeeding: use with caution; monitor the infant for possible effects.
  • Renal impairment: dose adjustment may be required in patients with reduced kidney function.
  • Elderly: increased sensitivity to sedation; monitor for drowsiness.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Levocetirizine can interact with other medicines; notable interactions are categorized below.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase levocetirizine plasma levels.
  • Ritonavir: can raise exposure and risk of side effects.
  • Other sedating antihistamines: additive central nervous system depression.
  • Alcohol: may enhance drowsiness and impair coordination.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase its clearance, reducing therapeutic effect.
  • Cimetidine: can modestly raise levocetirizine concentrations.
  • Fluvoxamine: may elevate plasma levels, requiring observation.

Frequently Asked Questions

Levocetirizina Aurobindo is indicated for the symptomatic relief of allergic rhinitis, including both seasonal and perennial forms, and for the treatment of chronic idiopathic urticaria. In these conditions it helps reduce nasal congestion, sneezing, itching, and the appearance of hives, providing improved comfort for patients.

Levocetirizine works by selectively antagonising peripheral histamine H1 receptors. By blocking these receptors, it prevents histamine‑induced vasodilation, increased vascular permeability, and nerve stimulation, which are the primary drivers of itching, sneezing, and swelling in allergic reactions. This targeted action reduces allergic manifestations while sparing central nervous system activity.

The dosing regimen for levocetirizine is determined by the prescribing clinician based on the patient’s age, renal function, and severity of symptoms. It is commonly administered once daily, but the exact dose and duration are individualized. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for levocetirizine in pregnancy are limited, so it should only be used if the potential benefit justifies any potential risk to the fetus. During breastfeeding, the drug may be excreted in milk; therefore, a healthcare professional should evaluate the risk‑benefit ratio before continuing therapy while nursing.

To place an order, submit an enquiry on the Levocetirizina Aurobindo product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine, offering effective H1‑receptor blockade with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Its rapid onset and once‑daily dosing make it convenient, while its selectivity provides comparable efficacy to other second‑generation drugs like cetirizine, often with improved tolerability.

Store Levocetirizina Aurobindo at ambient temperature below 25 °C. Keep the tablets in the original container, protect them from moisture, heat and direct light, and ensure the packaging remains tightly closed to maintain product stability throughout its shelf life.

Levocetirizina Aurobindo is taken orally, usually with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablet unless specifically instructed by their prescriber.

Serious adverse reactions, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or any signs of an allergic emergency while using the medication.

Levocetirizine should be avoided in individuals with known hypersensitivity to the drug or any of its excipients. Caution is advised for patients with severe renal impairment, as dose adjustment may be required, and for those who are pregnant or breastfeeding unless the benefits outweigh potential risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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