Product image of Levocetirizina Bluefish (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Bluefish

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Bluefish (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizina Bluefish, is a H1 receptor antagonist presented as an oral dosage form for oral use. It is employed to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children when appropriate.
GNH India supplies Levocetirizina Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

  • Levocetirizine acts on the histamine‑mediated allergic pathway and is indicated for several allergic conditions.
  • Allergic rhinitis: reduces sneezing, nasal itching, rhinorrhea and congestion.
  • Chronic idiopathic urticaria: diminishes wheal formation and itching.
  • Allergic conjunctivitis: alleviates eye redness, itching and tearing.

How It Works

  • Levocetirizine selectively binds to peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation. By blocking this receptor, the drug mitigates the classic signs of an allergic response without crossing the blood‑brain barrier in significant amounts, limiting central nervous system effects.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation.
  • Dry mouth.
  • Headache.
  • Nausea.
  • Fatigue.

Serious or Rare Side Effects

  • Angioedema or swelling of the face, lips, tongue.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic reactions requiring immediate medical attention.
  • Cardiac arrhythmias in susceptible individuals.
  • Hepatic injury manifested by abnormal liver enzymes.

Precautions & Warnings

  • Before initiating therapy, consider patient‑specific factors and monitor for adverse events.
  • Renal function assessment: dose adjustment may be needed in severe impairment.
  • Elderly patients: start at the lowest effective dose and monitor sedation.
  • Alcohol consumption: avoid or limit as it may enhance drowsiness.
  • Hypersensitivity history: discontinue if rash or swelling develops.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) that may increase plasma levels.
  • Alcohol, which can potentiate sedation.
  • Concurrent use of other sedating antihistamines.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol) where plasma concentrations may be altered.
  • Theophylline, as levocetirizine can modestly increase its levels.
  • Anticholinergic agents that may enhance dry‑mouth effects.

Frequently Asked Questions

Levocetirizina Bluefish contains levocetirizine, an H1 antihistamine indicated for the relief of symptoms associated with allergic rhinitis, such as sneezing and nasal congestion, and for the management of chronic idiopathic urticaria, helping to reduce wheals and itching. It may also be employed in related allergic eye conditions when prescribed.

Levocetirizine works by selectively binding to peripheral H1 histamine receptors, blocking histamine from activating these receptors. This inhibition prevents the cascade that leads to vasodilation, increased capillary permeability, and sensory nerve stimulation, thereby reducing the typical signs of an allergic reaction without significant central nervous system penetration.

The appropriate dose of Levocetirizina Bluefish is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function, and clinical response. Dosage instructions are individualized, and patients should follow the prescriber’s guidance without self‑adjusting the amount.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar antihistaminic efficacy with a potentially lower incidence of sedation because of its higher selectivity for peripheral H1 receptors. Both drugs treat allergic rhinitis and urticaria, but individual response and tolerability may differ, making prescriber judgment essential.

Levocetirizina Bluefish should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

The medication is taken orally, usually with a glass of water. It can be taken with or without food, according to the prescriber’s instructions. Swallow the tablet whole; do not crush or chew unless the formulation specifically permits it.

Serious adverse reactions, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and significant cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or any signs of an allergic emergency.

Individuals with known hypersensitivity to levocetirizine or any component of the formulation should not use the product. Caution is advised in patients with severe renal impairment, as dose adjustment may be required, and in those taking interacting medications that could increase the risk of sedation or other adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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