Product image of Levocetirizina Ciclum (Levocetirizine) supplied by GNH India

Levocetirizina Ciclum

Active Ingredient:
Levocetirizine
Origin:
EU

Levocetirizina Ciclum (Levocetirizine)

Levocetirizine, the active ingredient in Levocetirizina Ciclum, is an antihistamine presented as an oral tablet for oral use. It is employed to relieve symptoms of allergic rhinitis and to control chronic idiopathic urticaria in adults and children.
GNH India supplies Levocetirizina Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Levocetirizine acts on the H1‑histamine receptor pathway to manage allergic conditions.

  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and watery discharge.
  • Seasonal allergic rhinitis: provides symptom relief during pollen seasons.
  • Chronic idiopathic urticaria: diminishes hives and pruritus, improving quality of life.

How It Works

  • Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation. By inhibiting this receptor, the drug reduces the typical signs of allergic inflammation without crossing the blood‑brain barrier in significant amounts, limiting central nervous system effects.

Side Effects

Adverse reactions may occur with levocetirizine use.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Dry mouth: transient sensation of oral dryness.
  • Drowsiness: occasional mild sedation, especially at higher doses.
  • Fatigue: feeling of reduced energy or tiredness.

Serious or Rare Side Effects

  • Anaphylaxis: severe, potentially life‑threatening allergic reaction.
  • Angioedema: swelling of face, lips, tongue or throat.
  • Cardiac arrhythmia: rare reports of irregular heartbeat.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: dose adjustment may be required in severe impairment.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution with hepatic disease: monitor liver function tests periodically.
  • Monitor sedation: avoid operating machinery if drowsiness develops, especially with CNS depressants.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Ketoconazole: can increase levocetirizine plasma concentrations.
  • Erythromycin: may raise systemic exposure, enhancing side effects.
  • Ritonavir: potent CYP3A4 inhibitor that can elevate drug levels.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive sedative effect, increase drowsiness.
  • Other antihistamines: risk of cumulative antihistaminic activity.
  • Theophylline: may potentiate central nervous system depression.

Frequently Asked Questions

Levocetirizina Ciclum contains levocetirizine, an H1‑receptor antagonist indicated for the relief of symptoms associated with allergic rhinitis and for the control of chronic idiopathic urticaria, helping to reduce nasal congestion, sneezing, itching and the appearance of hives.

Levocetirizine works by selectively binding to peripheral H1 histamine receptors, blocking histamine from initiating the inflammatory cascade that causes vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby alleviating typical allergic symptoms.

The appropriate dose of Levocetirizina Ciclum is determined by the prescribing healthcare professional based on the patient’s age, condition severity, renal function and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for levocetirizine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it provides effective symptom control while crossing the blood‑brain barrier to a lesser extent, reducing central side effects.

Store Levocetirizina Ciclum at room temperature, below 25 °C, in the original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain product stability.

Levocetirizina Ciclum is taken orally, usually as a tablet swallowed whole with water. It can be taken with or without food, according to the prescriber’s guidance.

Serious adverse reactions, although rare, include anaphylaxis, angioedema, severe cardiac arrhythmias and significant hepatic dysfunction. Patients should seek immediate medical attention if they experience symptoms such as swelling of the face or throat, difficulty breathing, or unusual heart rhythm.

Levocetirizina Ciclum should be avoided in individuals with known hypersensitivity to levocetirizine or any excipients in the formulation. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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