Product image of Levocetirizina Doc Generici (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Doc Generici

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Doc Generici (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizina Doc Generici, is a second‑generation antihistamine presented as an oral dosage form for systemic use. It is employed to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children.

GNH India supplies Levocetirizina Doc Generici as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. All batches are manufactured under EU GMP guidelines and undergo full batch release testing before shipment.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Levocetirizine Dihydrochloride is a second‑generation antihistamine that targets histamine‑mediated allergic conditions.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or other seasonal allergens.
  • Chronic idiopathic urticaria: diminishes hives and associated itching, improving patient comfort.

How It Works

  • Levocetirizine Dihydrochloride acts as a selective antagonist of peripheral histamine H1 receptors. By binding to these receptors on mast cells, basophils and other target cells, it blocks the action of endogenous histamine released during allergic reactions. This inhibition prevents the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing typical allergic symptoms such as itching, swelling, and nasal discharge.

Side Effects

Levocetirizine Dihydrochloride may cause adverse reactions, which are categorized by frequency.

Common Side Effects

  • Drowsiness: mild sleepiness that may affect alertness.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring immediate attention.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: rapid, life‑threatening allergic response.

Precautions & Warnings

When using Levocetirizine Dihydrochloride, consider the following precautions.

  • Assess renal function: dose may need adjustment in patients with severe renal impairment.
  • Monitor for sedation: caution when operating machinery or driving.
  • Avoid in known hypersensitivity: discontinue if rash or swelling occurs.
  • Use with caution in pregnancy: discuss risks and benefits with a healthcare professional.
  • Use with caution in elderly: increased susceptibility to central nervous system effects.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levocetirizine Dihydrochloride can interact with other medicines; awareness helps manage risk.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase levocetirizine plasma levels.
  • Other sedating antihistamines: additive central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance drowsiness.
  • CNS depressants (e.g., benzodiazepines, opioids): may increase sedation.
  • CYP2D6 substrates (e.g., metoprolol): potential for altered metabolism.

Frequently Asked Questions

Levocetirizina Doc Generici contains levocetirizine dihydrochloride, a second‑generation antihistamine indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria. It helps reduce nasal congestion, sneezing, itching, and hives, improving overall comfort for patients with these allergic conditions.

Levocetirizine Dihydrochloride selectively blocks peripheral H1 histamine receptors. By preventing histamine from binding to these receptors on mast cells and other cells, it stops the cascade that causes vasodilation, increased vascular permeability, and nerve stimulation, thereby diminishing typical allergic signs such as itching, swelling, and nasal discharge.

The appropriate dose of Levocetirizina Doc Generici is determined by a qualified prescriber based on the patient’s age, clinical condition, and renal function. Healthcare professionals follow local prescribing guidelines to select the optimal regimen for each individual.

Safety data for levocetirizine during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Pregnant or nursing women should discuss their situation with a healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Levocetirizina Doc Generici. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizina is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it provides effective allergy relief while minimizing central nervous system effects, making it a preferred option for patients who need to maintain alertness.

Store Levocetirizina Doc Generici at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Levocetirizina Doc Generici is taken orally. The tablet should be swallowed whole with a glass of water, preferably at the same time each day. It can be taken with or without food, unless the prescribing physician provides specific instructions.

Serious adverse reactions, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or any signs of a severe allergic response.

Levocetirizina Doc Generici is contraindicated in individuals with known hypersensitivity to levocetirizine or any of the excipients in the formulation. Caution is also advised for patients with severe renal impairment, and it should be avoided in those who have experienced previous severe reactions to antihistamines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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