Product image of Levocetirizina Krka (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Krka

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Krka (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizina Krka, is a second‑generation antihistamine presented as a tablet for oral use. It reduces allergic symptoms such as sneezing, itching and hives in adults and children with allergic rhinitis or chronic idiopathic urticaria.

GNH India supplies Levocetirizina Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levocetirizine is used to manage allergic conditions that involve histamine‑mediated responses.

  • Allergic rhinitis: alleviates nasal congestion, sneezing and itching.
  • Chronic idiopathic urticaria: reduces the frequency and severity of hives and itching.
  • Allergic conjunctivitis: relieves eye itching, redness and tearing.

How It Works

  • Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this pathway, the drug diminishes the classic signs of an allergic response without readily crossing the blood‑brain barrier, which limits central sedation.

Side Effects

Levocetirizine may cause adverse reactions, which are generally mild but can be serious in rare cases.

Common Side Effects

  • Drowsiness: mild sleepiness, especially at treatment initiation.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Headache: transient cranial pain of varying intensity.
  • Fatigue: generalized lack of energy.

Serious or Rare Side Effects

  • Anaphylaxis: severe, potentially life‑threatening allergic reaction requiring immediate medical attention.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, presenting with widespread rash and mucosal involvement.

Precautions & Warnings

Levocetirizine should be used with caution in certain situations.

  • Dose adjustment in renal impairment: reduce dose according to renal function.
  • Avoid alcohol: may increase sedation.
  • Caution in elderly: monitor for increased drowsiness.
  • Pregnancy and lactation: use only if clearly needed after risk assessment.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levocetirizine may interact with other medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase levocetirizine plasma levels.
  • Alcohol and CNS depressants: additive sedation.
  • Ritonavir: may raise exposure and risk of side effects.

Moderate Interactions (Monitor Closely)

  • Theophylline: may reduce antihistamine effectiveness.
  • Anticholinergic drugs: may increase dry‑mouth sensation.
  • Other antihistamines: risk of additive antihistaminic effects.

Frequently Asked Questions

Levocetirizina Krka, containing levocetirizine, is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria. It helps reduce nasal congestion, sneezing, itching, and the appearance of hives in patients experiencing these allergic disorders.

Levocetirizine acts as a selective peripheral H1‑receptor antagonist. By binding to H1 receptors on mast cells and other tissues, it blocks histamine from triggering the cascade that causes vasodilation, increased permeability, and nerve irritation, thereby diminishing the typical signs of an allergic reaction.

The appropriate dose of Levocetirizina Krka is determined by the prescribing healthcare professional based on the patient’s age, renal function, and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine that offers effective symptom control with a lower incidence of sedation compared with first‑generation agents. Compared with other second‑generation drugs, it provides rapid onset and consistent efficacy, though individual response may vary.

Store Levocetirizina Krka at ambient temperature below 25 °C, in the original packaging, and protect it from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s potency and stability throughout its shelf life.

Levocetirizina Krka is taken orally, usually with or without food, as a single tablet per day. The exact timing and whether it should be taken with meals are determined by the prescribing clinician based on patient preference and tolerability.

The most serious risks, though rare, include anaphylactic reactions and severe skin disorders such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience symptoms like widespread rash, blistering, or difficulty breathing.

Levocetirizina Krka is contraindicated in individuals with known hypersensitivity to levocetirizine or any excipients in the tablet. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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