Product image of Levocetirizina Krka (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Krka

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Krka (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizina Krka, is a second‑generation antihistamine presented as a tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents by competitively blocking peripheral H1 receptors, thereby reducing sneezing, nasal itching, watery discharge, and skin wheal‑and‑flare reactions. GNH India supplies Levocetirizina Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Levocetirizine, a second‑generation antihistamine, acts on histamine‑mediated allergic pathways to relieve symptoms.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: reduces wheal formation, itching and flare reactions.
  • Allergic conjunctivitis: diminishes eye itching, redness and tearing.

How It Works

  • Levocetirizine is a selective, competitive antagonist of peripheral histamine H1 receptors. By binding to these receptors, it prevents histamine released during allergic reactions from triggering the intracellular signaling cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation, thereby mitigating the classic symptoms of allergy such as itching, swelling, and mucus production.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation
  • Headache
  • Dry mouth
  • Fatigue
  • Nausea
  • Abdominal discomfort

Serious or Rare Side Effects

  • Angioedema or swelling of the face, lips or tongue
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Anaphylactic reactions
  • Hepatic enzyme elevations
  • Cardiac arrhythmias in susceptible individuals

Precautions & Warnings

Levocetirizine should be used with appropriate clinical judgment.

  • Assess renal function: adjust dosage in patients with severe renal impairment.
  • Avoid in individuals with known hypersensitivity to levocetirizine or other piperazine antihistamines.
  • Use caution during pregnancy: consult a healthcare professional before initiating therapy.
  • Advise patients about possible drowsiness and to avoid operating machinery until they know how the drug affects them.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levocetirizine may interact with several concomitant medicines.

Major Interactions (Avoid)

  • Ketoconazole: can increase levocetirizine plasma concentrations.
  • Ritonavir: may raise levocetirizine levels leading to enhanced sedation.
  • Erythromycin: potential to elevate systemic exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depressant effect.
  • Other sedating antihistamines or CNS depressants: may increase drowsiness.
  • Theophylline: possible reduction in theophylline clearance, requiring monitoring.

Frequently Asked Questions

Levocetirizina Krka contains levocetirizine, which is indicated for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. It helps relieve nasal congestion, sneezing, itching, and skin wheal‑and‑flare reactions associated with these allergic disorders.

Levocetirizine selectively blocks peripheral H1 histamine receptors. By preventing histamine from binding to these receptors, it stops the cascade that causes vasodilation, increased vascular permeability, and nerve stimulation, thereby reducing the classic signs of an allergic response such as itching, swelling, and mucus production.

The appropriate dose of Levocetirizina Krka is determined by the prescribing healthcare professional based on the patient’s age, renal function, and severity of symptoms. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data in pregnancy and lactation are limited. Levocetirizine should only be used during pregnancy or while breastfeeding if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Levocetirizina Krka product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine that offers effective allergy relief with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Its rapid onset and once‑daily dosing make it a convenient alternative to other second‑generation antihistamines, though individual response may vary.

Levocetirizina Krka tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

The medication is taken orally, usually with or without food, as a single tablet per day. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare professional.

Serious but rare risks include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and significant hepatic enzyme elevations. Any signs of swelling, rash, or difficulty breathing require immediate medical attention.

Levocetirizina Krka should be avoided in individuals with known hypersensitivity to levocetirizine or other piperazine antihistamines. Caution is also advised for patients with severe renal impairment, and it should be used only under medical supervision during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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