Product image of Levocetirizina Mylan (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Mylan

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Mylan (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizina Mylan, is a second‑generation H1‑antihistamine presented as an oral tablet for oral use. It alleviates allergic symptoms such as sneezing, itching and hives in adults and children with allergic rhinitis or chronic urticaria.

GNH India supplies Levocetirizina Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan S.P.A.

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Indications & Clinical Uses

Levocetirizine is used to manage allergic conditions by blocking peripheral H1 receptors.

  • Seasonal allergic rhinitis: reduces nasal congestion, sneezing and itching caused by seasonal allergens.
  • Perennial allergic rhinitis: controls year‑round nasal symptoms due to continuous allergen exposure.
  • Chronic idiopathic urticaria: lessens the frequency and severity of hives and associated itching.

How It Works

  • Levocetirizine is a selective peripheral H1‑receptor antagonist. By binding with high affinity to the histamine H1 receptor on mast cells, basophils and other target cells, it prevents histamine from triggering the intracellular signaling cascade that leads to vasodilation, increased vascular permeability and sensory nerve activation. This inhibition reduces the immediate allergic response without readily crossing the blood‑brain barrier, limiting central sedation.

Side Effects

Levocetirizine may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Drowsiness: mild sleepiness, especially at treatment initiation.
  • Fatigue: general feeling of tiredness.
  • Dry mouth: reduced salivation.
  • Headache: transient cranial discomfort.
  • Nausea: mild gastrointestinal upset.
  • Dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or tongue.
  • Anaphylaxis: severe, life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: rare severe skin eruption.
  • Thrombocytopenia: low platelet count.
  • Hepatic injury: abnormal liver function tests.
  • Cardiac arrhythmia: irregular heart rhythm in predisposed patients.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess renal function: dose may need adjustment in severe renal impairment.
  • Known hypersensitivity: avoid in patients allergic to levocetirizine or other antihistamines.
  • Elderly patients: monitor for increased sedation.
  • Concomitant CNS depressants: avoid alcohol or sedatives that may enhance drowsiness.
  • Pregnancy and lactation: use only if benefit outweighs potential risk.
  • Store at room temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Levocetirizine can interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase levocetirizine plasma levels.
  • Alcohol or other sedatives: may potentiate central nervous system depression.
  • Ritonavir: may raise exposure to levocetirizine.

Moderate Interactions (Monitor Closely)

  • Theophylline: levocetirizine may increase theophylline concentrations.
  • Anticholinergic agents: may worsen dry mouth.
  • Other antihistamines: additive antihistaminic effect may increase sedation.

Frequently Asked Questions

Levocetirizina Mylan contains levocetirizine, which is indicated for the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria. It helps reduce sneezing, nasal congestion, itching, and hives in patients experiencing these allergic disorders.

Levocetirizine acts as a selective peripheral H1‑receptor antagonist. By binding to histamine H1 receptors on mast cells and basophils, it blocks histamine from initiating the cascade that causes vasodilation, increased vascular permeability, and nerve stimulation, thereby diminishing the typical signs of an allergic reaction.

The appropriate dose of Levocetirizina Mylan is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function, and severity of symptoms. Dosage recommendations are provided in the product’s prescribing information and should be followed exactly as directed by the prescriber.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Levocetirizina Mylan. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Both are second‑generation H1 antagonists, but levocetirizine may provide a more favorable side‑effect profile for patients who are sensitive to drowsiness, while maintaining strong antihistaminic activity.

Levocetirizina Mylan should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain product stability throughout its shelf life.

Levocetirizina Mylan is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet is swallowed whole with a glass of water and should be taken at the same time each day to maintain consistent blood levels.

Although uncommon, serious adverse reactions can include angioedema, anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome, thrombocytopenia, and hepatic injury. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or any signs of liver dysfunction.

Levocetirizina Mylan should not be used by individuals with a known hypersensitivity to levocetirizine or any component of the formulation. Caution is also advised for patients with severe renal impairment, pregnant or breastfeeding women unless clearly indicated, and those taking medications that may cause significant drug interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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