Product image of Levocetirizina Tarbis (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Tarbis

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Tarbis (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Levocetirizina Tarbis, is a H1 receptor antagonist presented as an oral tablet for oral use. It is employed to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and adolescents. It provides rapid relief of nasal congestion, sneezing, itching and watery eyes, and reduces the frequency and severity of hives and itching associated with chronic urticaria.

GNH India supplies Levocetirizina Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable logistics for global distribution.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Levocetirizine dihydrochloride is an antihistamine that targets H1‑mediated allergic pathways.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery eyes.
  • Seasonal allergic rhinitis: provides symptom relief during pollen exposure.
  • Chronic idiopathic urticaria: decreases the number and intensity of hives and associated itching.

How It Works

  • Levocetirizine dihydrochloride selectively binds to peripheral histamine H1 receptors, blocking the action of endogenous histamine. By preventing receptor activation, it inhibits the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic signs of allergic inflammation such as itching, swelling, and mucus production. The compound exhibits high affinity and rapid onset, with minimal penetration of the blood‑brain barrier, which limits central nervous system effects.

Side Effects

Levocetirizine dihydrochloride may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate pain often transient.
  • Dry mouth: sensation of oral dryness.
  • Drowsiness: mild sedation, especially at treatment initiation.
  • Fatigue: feeling of tiredness.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue requiring urgent care.
  • Anaphylactic reaction: severe allergic response with respiratory distress.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before prescribing levocetirizine, clinicians should consider several precautionary measures.

  • Renal function assessment: dose may need adjustment in severe renal impairment.
  • Pregnancy counseling: category B, use only if benefit outweighs risk.
  • Sedation monitoring: advise patients not to operate machinery if drowsy.
  • Concomitant CNS depressants: avoid or use with caution due to additive sedation.
  • Alcohol avoidance: limit intake to reduce drowsiness.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • Alcohol: enhances sedative effect.
  • Other antihistamines: additive CNS depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): possible altered metabolism.
  • Theophylline: may increase theophylline plasma concentration.
  • NSAIDs: risk of enhanced gastrointestinal irritation.
  • Tricyclic antidepressants: potential increased sedation.
  • Rifampin: may reduce levocetirizine exposure.

Frequently Asked Questions

Levocetirizina Tarbis contains levocetirizine dihydrochloride, an H1‑receptor antagonist indicated for the relief of symptoms associated with allergic rhinitis and for the management of chronic idiopathic urticaria. It helps reduce nasal congestion, sneezing, itching, watery eyes, and the frequency and severity of hives.

Levocetirizine works by selectively binding to peripheral histamine H1 receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation. This blockade reduces the classic allergic signs of itching, swelling, and mucus production without significant penetration of the central nervous system.

The exact dose is determined by the prescribing healthcare professional based on the patient’s age, renal function, and clinical response. In most adult cases, a single daily dose is typical, but the prescriber will set the appropriate strength and frequency for each individual.

Levocetirizine is classified as pregnancy category B, indicating that animal studies have not shown risk and there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies the potential risk. Limited data suggest it is compatible with breastfeeding, but a clinician should evaluate each case.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering higher affinity for the H1 receptor and a lower incidence of central nervous system sedation compared with first‑generation antihistamines. Compared with other second‑generation agents, its efficacy in controlling urticaria is comparable, while its rapid onset and once‑daily dosing are advantageous.

The product should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral tablet formulation.

Levocetirizina Tarbis is taken orally, usually with a glass of water. It can be taken with or without food, and patients should follow the dosing instructions provided by their healthcare professional. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious adverse reactions, although rare, include angioedema (swelling of the face, lips, tongue), anaphylactic reactions, and severe skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they experience rapid swelling, difficulty breathing, or widespread rash.

Levocetirizina Tarbis should be avoided in individuals with known hypersensitivity to levocetirizine or any excipients in the tablet. It is also contraindicated in patients with severe renal impairment unless dose adjustment is made, and it should be used with caution in children under the age for which safety has not been established.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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