Product image of Levocetirizina Zentiva (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizina Zentiva

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizina Zentiva (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizina Zentiva, is an antihistamine presented as an oral formulation for oral use. It is indicated for the relief of symptoms such as nasal congestion, sneezing, itching and watery eyes in allergic rhinitis, and for reducing hives and itching in chronic idiopathic urticaria in adults and adolescents.
GNH India supplies Levocetirizina Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

Levocetirizine Dihydrochloride is an antihistamine that acts on peripheral H1 receptors to control allergic conditions.

  • Allergic rhinitis: Reduces nasal congestion, sneezing, itching and watery eyes associated with seasonal or perennial allergies.
  • Chronic idiopathic urticaria: Decreases frequency and severity of hives and associated itching.
  • Allergic conjunctivitis: Alleviates eye itching, redness and tearing caused by histamine release.

How It Works

  • Levocetirizine Dihydrochloride selectively blocks peripheral H1‑histamine receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug reduces the immediate allergic response without crossing the blood‑brain barrier in significant amounts, thereby limiting central sedation. The high affinity for the H1 subtype ensures prolonged receptor occupancy, providing 24‑hour symptom control after a single oral dose.

Side Effects

Levocetirizine Dihydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate headache.
  • Dry mouth: sensation of oral dryness.
  • Drowsiness: mild somnolence, especially at initiation.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic dysfunction: elevated liver enzymes.

Precautions & Warnings

Before prescribing Levocetirizine Dihydrochloride, clinicians should consider several precautionary measures.

  • Renal impairment: dose adjustment may be required in patients with reduced kidney function.
  • Elderly patients: monitor for increased sedation or confusion.
  • Pregnancy and lactation: use only if potential benefit outweighs risk.
  • Concomitant CNS depressants: avoid additive drowsiness.
  • Driving and machinery: caution advised if somnolence occurs.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Levocetirizine Dihydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Ketoconazole: strong CYP3A4 inhibitors may increase levocetirizine plasma levels.
  • Ritonavir: potent CYP3A4 inhibition can raise drug concentration, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance drowsiness.
  • Other antihistamines: additive sedation.
  • Theophylline: may reduce antihistaminic effect.

Frequently Asked Questions

Levocetirizina Zentiva contains levocetirizine dihydrochloride, an antihistamine indicated for the relief of symptoms associated with allergic rhinitis such as nasal congestion, sneezing and itchy eyes, as well as for managing chronic idiopathic urticaria, reducing the frequency and severity of hives and itching.

Levocetirizine works by selectively blocking peripheral H1‑histamine receptors. This inhibition prevents histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation, thereby reducing the typical signs of an allergic response without significant central nervous system effects.

The appropriate dose of Levocetirizina Zentiva is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, and renal function. The prescriber will set the exact regimen according to current medical guidelines and individual patient needs.

Safety data for levocetirizine during pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizina Zentiva is the active enantiomer of cetirizine, offering a higher affinity for the H1 receptor and potentially a more rapid onset of action with a lower incidence of sedation compared with some first‑generation antihistamines, while providing comparable efficacy to other second‑generation agents.

The product should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Levocetirizina Zentiva is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious adverse reactions, although rare, include anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and significant hepatic dysfunction. Patients should seek immediate medical attention if they experience symptoms like rash, swelling, difficulty breathing, or jaundice.

Levocetirizina Zentiva is contraindicated in individuals with known hypersensitivity to levocetirizine or any of the tablet’s excipients. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking other CNS depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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