Product image of Levocetirizine Cristers (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Cristers

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Cristers (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizine Cristers, is a second‑generation antihistamine presented as an oral tablet for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in adults and adolescents and can be used in patients seeking non‑sedating allergy relief.

GNH India supplies Levocetirizine Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures consistent quality and regulatory compliance across all markets.

Manufacturer / TM Owner

Cristers

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Indications & Clinical Uses

  • Levocetirine, a second‑generation antihistamine, acts on histamine‑mediated allergic pathways to alleviate symptoms.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: decreases frequency and severity of hives and itching.
  • Allergic conjunctivitis: helps relieve ocular itching and tearing.

How It Works

  • Levocetirizine selectively blocks peripheral H1‑histamine receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, it reduces the classic signs of allergic inflammation without significant central nervous system penetration, which accounts for its lower sedative profile compared with first‑generation antihistamines.

Side Effects

Levocetirine may cause adverse reactions, which are generally mild but can be serious in rare cases.

Common Side Effects

  • Headache
  • Dry mouth
  • Drowsiness
  • Fatigue
  • Nausea
  • Altered taste perception

Serious or Rare Side Effects

  • Angioedema or severe swelling of the face, lips or throat
  • Severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Anaphylactic reaction requiring immediate medical attention
  • Elevation of liver enzymes or hepatic dysfunction
  • Blood dyscrasias including neutropenia or thrombocytopenia
  • Cardiac arrhythmias in susceptible individuals

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Assess renal function: dose may need adjustment in severe renal impairment.
  • Avoid use in patients with known hypersensitivity to levocetirizine or other antihistamines.
  • Caution in hepatic impairment: monitor liver function tests periodically.
  • Monitor for excessive sedation if combined with alcohol or CNS depressants.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levocetirine can interact with other substances; awareness helps minimize risk.

Major Interactions (Avoid)

  • Alcohol and other CNS depressants: may increase drowsiness and impair cognition.
  • Concurrent use with other antihistamines: risk of additive sedation.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase plasma concentrations of levocetirine.
  • Strong CYP3A4 inhibitors such as ritonavir: may raise levocetirine levels.
  • Ketoconazole: potential increase in exposure requiring clinical monitoring.

Frequently Asked Questions

Levocetirizine Cristers is an oral antihistamine indicated for the relief of symptoms associated with allergic rhinitis, such as sneezing, nasal congestion, and itching, as well as for the management of chronic idiopathic urticaria to reduce the frequency and severity of hives and itching.

Levocetirizine works by selectively blocking peripheral H1‑histamine receptors. This prevents histamine from binding to its receptors on blood vessels and sensory nerves, thereby reducing vasodilation, increased permeability, and the nerve stimulation that cause typical allergic symptoms.

The specific dose is determined by the prescribing healthcare professional based on the patient’s age, condition, and renal function. In many adult cases, a single tablet taken once daily is common, but the exact regimen should always follow the prescriber’s instructions.

Safety data in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering comparable antihistaminic efficacy with a slightly lower incidence of sedation for many patients. Both belong to the second‑generation antihistamine class, but levocetirizine may provide a more favorable side‑effect profile in some individuals.

Store the product at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not refrigerate unless specifically instructed on the label, and keep the container tightly closed to maintain product stability.

Levocetirizine Cristers is taken orally. Swallow the tablet whole with a glass of water, with or without food, as directed by the prescriber. Consistency in the time of day helps maintain steady blood levels.

While uncommon, serious adverse events can include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, significant liver enzyme elevations, and rare blood disorders. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or signs of an allergic reaction.

Individuals with a known hypersensitivity to levocetirizine, other antihistamines, or any excipients in the formulation should avoid the product. Patients with severe renal impairment should not use it without dose adjustment, and anyone advised otherwise by a healthcare professional should refrain from use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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