Product image of Levocetirizine Dihcl Sandoz (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Dihcl Sandoz

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Dihcl Sandoz (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizine Dihcl Sandoz, is an antihistamine presented as an oral tablet for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in adults and children when appropriate.
GNH India supplies Levocetirizine Dihcl Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz B.V.

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Indications & Clinical Uses

Levocetirizine Dihcl Sandoz is an antihistamine that targets H1‑mediated allergic pathways. It is used for:

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
  • Chronic idiopathic urticaria: alleviates hives and associated itching.
  • Seasonal allergic rhinitis (hay fever): controls typical seasonal allergy symptoms.

How It Works

  • Levocetirizine selectively antagonizes peripheral H1 histamine receptors, preventing histamine from binding and activating the receptor cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By blocking this pathway, it diminishes the classic signs of an allergic response without crossing the blood‑brain barrier in significant amounts, limiting central nervous system effects.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness: mild to moderate sleepiness, especially after the first dose.
  • Dry mouth: reduced salivation causing throat discomfort.
  • Headache: transient tension‑type headache.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or tongue requiring urgent care.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: rare systemic allergic reaction with respiratory or circulatory compromise.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Renal function assessment: dose adjustment may be needed in severe renal impairment.
  • Elderly patients: monitor for increased sedation or dizziness.
  • Alcohol consumption: avoid or limit as it may enhance drowsiness.
  • Concomitant CNS depressants: use caution when combined with sedatives or hypnotics.
  • Pediatric use: not recommended for children under six years of age unless specifically prescribed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels.
  • Alcohol: can potentiate sedation and impair alertness.
  • Central nervous system depressants (e.g., benzodiazepines): risk of additive drowsiness.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., itraconazole): may modestly raise levocetirizine exposure.
  • Macrolide antibiotics (e.g., erythromycin): potential for increased sedation.
  • Theophylline: levocetirizine may slightly raise theophylline concentrations.

Frequently Asked Questions

Levocetirizine Dihcl Sandoz is prescribed to relieve symptoms of allergic rhinitis, including seasonal hay fever, and to manage chronic idiopathic urticaria (hives). It works by reducing nasal congestion, sneezing, itching, and the formation of hives, providing symptomatic relief for patients with these allergic conditions.

Levocetirizine is a selective antagonist of peripheral H1 histamine receptors. By blocking histamine from binding to these receptors, it prevents the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation, thereby reducing the typical signs of an allergic reaction such as itching, swelling, and nasal discharge.

The appropriate dose of Levocetirizine Dihcl Sandoz is determined by the prescribing healthcare professional based on the patient’s age, renal function, and severity of symptoms. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for levocetirizine in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any possible risks before prescribing it to pregnant or nursing women. Patients should discuss their individual situation with their doctor to determine if the medication is appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levocetirizine is the active R‑enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it has a more favorable side‑effect profile and does not readily cross the blood‑brain barrier, making it a preferred option for many patients requiring daily allergy control.

Store the tablets at room temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed to maintain product stability throughout its shelf life.

Levocetirizine Dihcl Sandoz is taken orally, usually as a tablet, with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

While generally safe, serious adverse reactions can include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and rare cases of anaphylaxis. Patients experiencing swelling of the face, lips, tongue, or difficulty breathing should seek immediate medical attention.

Levocetirizine should be avoided in individuals with known hypersensitivity to levocetirizine or any component of the formulation. Caution is also advised for patients with severe renal impairment, and it is not recommended for children under six years of age unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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