Levocetirizine Dihydrochloride Aurobindo (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride acts on histamine‑mediated allergic pathways and is indicated for the following conditions:

• Allergic rhinitis: reduces sneezing, nasal itching, rhinorrhea and congestion.
• Chronic idiopathic urticaria: alleviates hives and associated itching.
• Seasonal allergic rhinitis: controls symptoms triggered by pollen exposure.

• Levocetirizine dihydrochloride selectively blocks peripheral histamine H1 receptors, preventing histamine from binding to its target cells. This antagonism reduces the vascular permeability, sensory nerve activation, and mucus secretion that underlie the clinical manifestations of allergic reactions, thereby providing symptomatic relief without significant central nervous system effects.

Levocetirizine dihydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Drowsiness: mild to moderate sedation.
• Dry mouth: reduced salivation.
• Headache: transient cranial discomfort.
• Fatigue: feeling of tiredness.
• Nausea: mild gastrointestinal upset.
• Altered taste: temporary metallic or bitter sensation.

Serious or Rare Side Effects

• Angioedema: swelling of face, lips or tongue.
• Severe skin reactions: such as Stevens‑Johnson syndrome.
• Anaphylaxis: acute, life‑threatening allergic response.
• Tachycardia: rapid heart rate.
• Hepatic dysfunction: abnormal liver enzymes.
• Blood dyscrasias: rare hematologic abnormalities.

When using Levocetirizine dihydrochloride, consider the following precautions:

• Pregnancy: consult a healthcare provider before use.
• Breastfeeding: assess risk versus benefit with a clinician.
• Renal impairment: dose may require adjustment in reduced kidney function.
• Elderly patients: monitor for increased sedation.
• Driving or operating machinery: avoid if drowsiness occurs.
• Store at room temperature: keep in the original container, protect from moisture and light.

Levocetirizine dihydrochloride may interact with other medicines. Review the following categories:

Major Interactions (Avoid)

• Alcohol: can enhance sedative effects.
• Central nervous system depressants (e.g., benzodiazepines): additive drowsiness.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise plasma concentrations.

Moderate Interactions (Monitor Closely)

• Theophylline: levocetirizine may increase its clearance.
• Ritonavir: may elevate levocetirizine exposure.
• Anticholinergic agents: may worsen dry‑mouth symptoms.