Product image of Levocetirizine Dihydrochloride Brillpharma (Ireland) (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Dihydrochloride Brillpharma (Ireland)

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Dihydrochloride Brillpharma (Ireland) (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizine Dihydrochloride Brillpharma, is an antihistamine presented as an oral dosage form for oral use. It is employed to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children where appropriate.
GNH India supplies Levocetirizine Dihydrochloride Brillpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Brillpharma (Ireland) Limited

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Indications & Clinical Uses

Levocetirizine Dihydrochloride acts on the histamine H1 receptor pathway to control allergic conditions.

  • Allergic rhinitis: reduces nasal congestion, sneezing and itching.
  • Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or outdoor allergens.
  • Chronic idiopathic urticaria: diminishes wheal formation and pruritus associated with chronic hives.

How It Works

  • Levocetirizine Dihydrochloride selectively blocks peripheral histamine H1 receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug reduces the classic signs of allergic inflammation without crossing the blood‑brain barrier in significant amounts.

Side Effects

Levocetirizine Dihydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness: mild sedation may be experienced.
  • Headache: transient headache reported by some patients.
  • Dry mouth: reduced salivation leading to a dry oral cavity.
  • Fatigue: a feeling of tiredness without exertion.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, or tongue requiring immediate attention.
  • Severe skin rash: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic reaction: rare systemic allergic response that can be life‑threatening.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Pregnancy: consult a healthcare professional to weigh potential benefits against risks.
  • Breastfeeding: assess the need for treatment and possible infant exposure.
  • Renal impairment: dose adjustment may be necessary in patients with reduced kidney function.
  • Elderly patients: monitor for increased sedation or dizziness.
  • Concomitant CNS depressants: may potentiate drowsiness and should be used with caution.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Levocetirizine Dihydrochloride can interact with several drug classes.

Major Interactions (Avoid)

  • Alcohol: may enhance sedative effects.
  • Other antihistamines: additive antihistaminic activity can increase side‑effects.
  • Strong CYP3A4 inhibitors: may raise plasma concentrations of levocetirizine.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): monitor for excessive drowsiness.
  • Theophylline: levocetirizine may increase theophylline levels, requiring observation.

Frequently Asked Questions

Levocetirizine Dihydrochloride is indicated for the relief of symptoms associated with allergic rhinitis, including seasonal and perennial forms, and for the management of chronic idiopathic urticaria, where it helps reduce itching, wheal formation, and nasal congestion.

The drug works by selectively antagonising peripheral histamine H1 receptors. By blocking histamine binding, it prevents the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation, thereby reducing the typical signs of an allergic response.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, condition severity, renal function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety in pregnancy and lactation has not been definitively established. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing to pregnant or nursing women, and patients should discuss their situation with a qualified professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a potentially lower incidence of sedation. Compared with first‑generation antihistamines, it has reduced central nervous system penetration, resulting in fewer drowsy side‑effects while maintaining strong H1‑receptor blockade.

The product should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. No refrigeration is required for this oral formulation.

Levocetirizine Dihydrochloride is taken orally, usually as a tablet or similar solid dosage form, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water.

Serious risks, although rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or signs of an allergic reaction.

Individuals with known hypersensitivity to levocetirizine, cetirizine, or any component of the formulation should avoid the drug. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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