Product image of Levocetirizine Dihydrochloride Ennogen Healthcare (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Dihydrochloride Ennogen Healthcare

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Dihydrochloride Ennogen Healthcare (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizine Dihydrochloride Ennogen Healthcare, is a second‑generation antihistamine presented as an oral dosage form for oral use. It is used to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children when appropriate.
GNH India supplies Levocetirizine Dihydrochloride Ennogen Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ennogen Healthcare Limited

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Indications & Clinical Uses

Levocetirizine Dihydrochloride is a selective H1‑receptor antagonist that alleviates allergic conditions by blocking peripheral histamine activity.

  • Allergic rhinitis: reduces nasal congestion, sneezing, and itching.
  • Chronic idiopathic urticaria: diminishes wheal formation and itching.
  • Allergic conjunctivitis: eases eye redness, tearing, and irritation.

How It Works

  • Levocetirizine Dihydrochloride selectively binds to peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this pathway, the drug reduces the classic signs of allergic inflammation without readily crossing the blood‑brain barrier, limiting central sedation.

Side Effects

Levocetirizine Dihydrochloride is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Drowsiness: mild to moderate sleepiness.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivation.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, or throat.
  • Anaphylaxis: severe, life‑threatening allergic reaction.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Levocetirizine Dihydrochloride, consider the following safety points.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: weigh potential benefits against risks to the infant.
  • Renal impairment: dose adjustment may be required in reduced kidney function.
  • Elderly patients: monitor for increased sedation or confusion.
  • Driving or operating machinery: avoid if drowsiness occurs.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine Dihydrochloride can interact with other substances that affect the central nervous system or drug metabolism.

Major Interactions (Avoid)

  • Alcohol: may enhance sedative effects.
  • CNS depressants (e.g., benzodiazepines): additive drowsiness.
  • Ritonavir: can increase levocetirizine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Theophylline: levocetirizine may raise theophylline levels.
  • Ketoconazole: may elevate levocetirizine exposure.
  • Anticholinergic agents: may worsen dry mouth.

Frequently Asked Questions

Levocetirizine Dihydrochloride is prescribed to manage symptoms of allergic rhinitis, such as sneezing, nasal congestion, and itching, as well as chronic idiopathic urticaria, where it helps reduce hives and associated itching. It may also be used for other allergic eye or skin reactions under medical guidance.

The drug works by selectively blocking peripheral H1 histamine receptors, which prevents histamine from binding and triggering the inflammatory cascade that causes vasodilation, increased permeability, and nerve stimulation. This inhibition reduces the typical signs of an allergic response without significantly affecting the central nervous system.

The appropriate dose of Levocetirizine Dihydrochloride is determined by a qualified prescriber based on the patient’s age, weight, renal function, and specific indication. Patients should follow the exact dosing instructions provided on the prescription label and not adjust the dose on their own.

Safety data for Levocetirizine Dihydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine, offering effective relief of allergic symptoms with a lower likelihood of sedation compared with first‑generation agents like diphenhydramine. Its rapid onset and once‑daily dosing make it convenient, though individual response can vary among patients.

Store the product at room temperature, preferably below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain potency and stability throughout its shelf life.

Levocetirizine Dihydrochloride is taken orally, usually as a tablet, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious adverse reactions, though rare, include angioedema, anaphylaxis, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience swelling of the face or throat, difficulty breathing, or widespread rash.

Individuals with known hypersensitivity to levocetirizine, cetirizine, or any component of the formulation should avoid the drug. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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