Levocetirizine Dihydrochloride Strandhaven T/A Somex Pharma (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride acts on histamine‑mediated allergic pathways and is used for the following conditions:

• Allergic rhinitis: alleviates nasal congestion, sneezing, and itching.
• Seasonal allergic rhinitis: reduces seasonal nasal and ocular symptoms.
• Chronic idiopathic urticaria: diminishes hives and associated itching.

• Levocetirizine Dihydrochloride selectively blocks peripheral histamine H1 receptors, preventing histamine from binding and activating these receptors. This antagonism reduces the vascular permeability, sensory nerve stimulation, and smooth‑muscle contraction that underlie the clinical manifestations of allergic reactions, thereby providing symptomatic relief.

Levocetirizine Dihydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Headache: mild to moderate intensity.
• Dry mouth: transient sensation of oral dryness.
• Drowsiness or fatigue: occasional somnolence.
• Nausea: mild gastrointestinal upset.
• Abdominal pain: intermittent discomfort.
• Taste alteration: temporary change in taste perception.

Serious or Rare Side Effects

• Angioedema: swelling of face, lips, or tongue.
• Anaphylaxis: severe, life‑threatening allergic reaction.
• Severe skin reactions: such as Stevens‑Johnson syndrome.
• Liver enzyme elevation: abnormal hepatic function tests.
• Blood dyscrasias: rare hematologic abnormalities.
• Cardiac arrhythmia: uncommon rhythm disturbances.

Before initiating therapy with Levocetirizine Dihydrochloride, consider the following precautions:

• Pregnancy: consult a healthcare professional before use.
• Breastfeeding: discuss potential risks with a physician.
• Renal impairment: dose adjustment may be required.
• Elderly patients: monitor for increased sedation.
• Driving or operating machinery: avoid if drowsiness occurs.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Levocetirizine Dihydrochloride may interact with other medicines. Review the following categories:

Major Interactions (Avoid)

• Ketoconazole: can increase levocetirizine plasma levels.
• Ritonavir: may raise levocetirizine concentrations.
• Other sedating antihistamines: additive central nervous system depression.

Moderate Interactions (Monitor Closely)

• Alcohol: may enhance drowsiness.
• Theophylline: possible reduction of antihistamine effect.
• Cimetidine: may modestly increase levocetirizine exposure.