Product image of Levocetirizine Eg (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Eg

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Eg (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizine Eg, is a second‑generation H1 receptor antagonist presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and children when prescribed.

GNH India supplies Levocetirizine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

  • Levocetirizine is a second‑generation antihistamine that alleviates allergic conditions by blocking peripheral H1 receptors.
  • Allergic rhinitis: reduces sneezing, nasal congestion, itching and rhinorrhea.
  • Chronic idiopathic urticaria: decreases wheal formation and itching, improving quality of life.

How It Works

  • Levocetirizine selectively binds to peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By blocking this receptor, it reduces the typical symptoms of allergic reactions without readily crossing the blood‑brain barrier, limiting central nervous system effects.

Side Effects

Levocetirizine is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Drowsiness or mild sedation.
  • Headache.
  • Dry mouth.
  • Fatigue.
  • Altered taste perception.
  • Nausea.

Serious or Rare Side Effects

  • Angioedema or severe swelling.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic reactions.
  • Cardiac arrhythmia (rare).
  • Hepatic enzyme elevation.
  • Severe psychiatric symptoms (rare).

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Pregnancy: consult a healthcare provider; use only if benefit outweighs risk.
  • Renal impairment: dose may require adjustment; monitor renal function.
  • Elderly patients: increased sensitivity to sedation; start with lowest effective dose.
  • Driving or operating machinery: avoid if drowsiness occurs.
  • Drug interactions: review all concomitant medications for potential additive effects.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levocetirizine may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

  • Alcohol: may enhance sedation.
  • Central nervous system depressants (e.g., benzodiazepines): additive drowsiness.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase levocetirizine plasma levels.

Moderate Interactions (Monitor Closely)

  • Theophylline: possible reduction in antihistamine efficacy.
  • Ritonavir: may raise levocetirizine concentrations.
  • Other antihistamines: risk of cumulative anticholinergic effects.

Frequently Asked Questions

Levocetirizine Eg is indicated for the symptomatic relief of allergic rhinitis and for the treatment of chronic idiopathic urticaria. It helps reduce sneezing, nasal congestion, itching, and skin wheals associated with these allergic conditions.

Levocetirizine acts as a selective peripheral H1‑receptor antagonist. By binding to H1 receptors, it blocks histamine‑induced vasodilation, increased vascular permeability, and sensory nerve activation, thereby alleviating the typical signs of an allergic response.

The prescribed dose is determined by the treating clinician based on the patient’s age, weight, renal function and severity of symptoms. In many adult patients a common regimen is 5 mg once daily, but the exact schedule must be set by a qualified healthcare professional.

Safety data in pregnancy and lactation are limited. Levocetirizine should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levocetirizine is the active (R‑) enantiomer of cetirizine, offering similar antihistaminic efficacy with a potentially lower incidence of sedation. Both belong to the second‑generation H1‑antagonist class, but levocetirizine may provide a more favorable side‑effect profile for some patients.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Levocetirizine Eg is taken orally, usually as a tablet. It can be swallowed with or without food. Patients should follow the prescribing clinician’s instructions and avoid crushing or chewing the tablet unless specifically directed.

Rare but serious adverse reactions include angioedema, anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and, in exceptional cases, cardiac arrhythmias or severe hepatic enzyme elevations. Immediate medical attention is required if any of these symptoms appear.

Patients with known hypersensitivity to levocetirizine or any component of the formulation should avoid the drug. Those with severe renal impairment should not use it without dose adjustment and close monitoring. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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