Product image of Levocetirizine Eg (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Eg

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Eg (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizine Eg, is a second‑generation antihistamine presented as an oral tablet for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in appropriate patient populations.

GNH India supplies Levocetirizine Eg as a licensed, GDP‑compliant international pharmaceutical product, adhering to EU quality standards. The company provides reliable sourcing to hospitals, pharmacies and clinics worldwide, supporting global procurement with regulatory documentation and consistent batch release and timely delivery.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

  • Levocetirizine is a second‑generation antihistamine that acts on histamine‑mediated allergic conditions.
  • Allergic rhinitis: reduces sneezing, nasal itching, rhinorrhea and congestion.
  • Seasonal allergic rhinitis: provides symptom control during pollen seasons.
  • Chronic idiopathic urticaria: alleviates wheals and itching associated with chronic hives.

How It Works

  • Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor activity, it reduces the classic signs of allergic inflammation without readily crossing the blood‑brain barrier, which limits central nervous system effects.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation.
  • Headache.
  • Dry mouth.
  • Fatigue.
  • Nausea.
  • Altered taste perception.

Serious or Rare Side Effects

  • Angioedema or severe swelling of face, lips or throat.
  • Anaphylactic reactions.
  • Hepatic enzyme elevation.
  • Neutropenia or other blood dyscrasias.
  • Severe skin rash such as Stevens‑Johnson syndrome.
  • Cardiovascular arrhythmias (very rare).

Precautions & Warnings

  • When prescribing Levocetirizine, clinicians should consider several safety aspects.
  • Assess renal function: dose adjustment may be required in severe renal impairment.
  • Monitor for sedation: advise patients to avoid operating machinery if drowsiness occurs.
  • Avoid use in known hypersensitivity: discontinue immediately if allergic reaction develops.
  • Use with caution in pregnancy: limited data, prescribe only if benefit outweighs risk.
  • Review concomitant CNS depressants: potential additive sedation.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase levocetirizine plasma levels.
  • Monoamine oxidase inhibitors (MAOIs) can potentiate antihistaminic effects.

Moderate Interactions (Monitor Closely)

  • Alcohol or other CNS depressants: may enhance sedation.
  • Other antihistamines or anticholinergic agents: risk of additive anticholinergic burden.
  • Certain antibiotics (e.g., erythromycin): may modestly raise drug concentrations.

Frequently Asked Questions

Levocetirizine Eg is indicated for the symptomatic relief of allergic rhinitis—including seasonal and perennial forms—and for the treatment of chronic idiopathic urticaria. It helps reduce sneezing, nasal itching, runny nose, and itching or swelling associated with hives.

Levocetirizine works by selectively blocking peripheral H1 histamine receptors. This prevents histamine from binding to its receptors on blood vessels and sensory nerves, thereby reducing vasodilation, increased permeability, and the itching and swelling that characterize allergic reactions.

The exact dose is determined by the prescribing clinician based on the patient’s age, renal function and clinical response. In many regions an adult dose of 5 mg once daily is common, but the prescriber may adjust the regimen to suit individual needs.

Safety data in pregnancy are limited, and the drug should only be used if the potential benefit justifies any possible risk to the fetus. Levocetirizine is excreted in breast milk in small amounts; nursing mothers should discuss use with their healthcare provider.

To place an order, submit an enquiry on the Levocetirizine Eg product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine, offering effective H1‑receptor blockade with a lower propensity for sedation compared with first‑generation agents such as diphenhydramine. Its rapid onset and once‑daily dosing make it convenient, while maintaining a favorable safety profile.

Store the tablets at room temperature, below 25 °C, in the original container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Levocetirizine Eg is taken orally, usually as a whole tablet swallowed with a glass of water. It can be taken with or without food, and the dose is typically administered once daily at the same time each day.

Although rare, serious adverse reactions include angioedema, severe skin rashes such as Stevens‑Johnson syndrome, anaphylaxis, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or signs of an allergic reaction.

Levocetirizine should be avoided in individuals with known hypersensitivity to the drug or any of its excipients. It is also contraindicated in patients with severe renal impairment unless dose‑adjusted, and it is not recommended for children below the approved age without specific medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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