Product image of Levocetirizine Hasco (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Hasco

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Hasco (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizine Hasco, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and children.

GNH India supplies Levocetirizine Hasco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Levocetirizine is a selective H1‑receptor antagonist used to manage allergic disorders.

  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and watery discharge.
  • Seasonal allergic rhinitis: reduces symptoms triggered by pollen or other seasonal allergens.
  • Chronic idiopathic urticaria: diminishes hives and associated itching, improving quality of life.

How It Works

  • Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this pathway, the drug reduces the classic signs of allergic inflammation without readily crossing the blood‑brain barrier, limiting central sedation.

Side Effects

Levocetirizine is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Drowsiness: mild sleepiness, especially at treatment initiation.
  • Dry mouth: reduced salivation causing throat discomfort.
  • Headache: transient tension‑type headache.
  • Nausea: occasional stomach upset.
  • Taste alteration: metallic or altered taste perception.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or tongue requiring urgent care.
  • Anaphylactic reaction: severe, systemic allergic response.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Cardiac arrhythmia: rare reports of QT prolongation.

Precautions & Warnings

Before using Levocetirizine, consider the following safety measures.

  • Renal function assessment: dose may need adjustment in severe renal impairment.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Sedation monitoring: avoid operating machinery if drowsiness occurs.
  • Pediatric use: not recommended for children under six years without medical advice.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Other sedating antihistamines: additive drowsiness.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Alcohol: enhances central nervous system depression.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, opioids): monitor for enhanced sedation.
  • Anticholinergic agents (e.g., diphenhydramine): may increase dry‑mouth risk.
  • Theophylline: possible alteration of its plasma concentration.

Frequently Asked Questions

Levocetirizine Hasco contains the antihistamine levocetirizine, which is indicated for the relief of symptoms associated with allergic rhinitis—including sneezing, runny nose, and itchy eyes—as well as for chronic idiopathic urticaria, where it helps reduce hives and itching. These uses are based on its ability to block peripheral H1 receptors that mediate allergic responses.

Levocetirizine works by selectively binding to H1 histamine receptors on peripheral tissues, preventing histamine from triggering the cascade that leads to vasodilation, increased capillary permeability, and nerve stimulation. This inhibition reduces the classic signs of an allergic reaction, such as swelling, itching, and mucus production, while its limited penetration of the blood‑brain barrier minimizes central sedation.

The appropriate dose of Levocetirizine Hasco is determined by a qualified prescriber based on the patient’s age, clinical condition, and renal function. Healthcare professionals follow established guidelines, typically prescribing a once‑daily oral dose, but the exact regimen should be confirmed with the treating physician.

Safety of levocetirizine during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy, as the prescriber may weigh the severity of allergic symptoms against any possible fetal or infant exposure.

To request Levocetirizine Hasco, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levocetirizine is a second‑generation H1 antihistamine, offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Its rapid onset and once‑daily dosing make it convenient, while its selectivity for peripheral H1 receptors provides comparable efficacy to other second‑generation drugs like cetirizine, often with a more favorable side‑effect profile.

Levocetirizine Hasco should be stored at room temperature, below 25 °C (77 °F). Keep the tablets in the original blister pack or bottle, protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

Levocetirizine Hasco is taken orally, usually as a tablet swallowed whole with a glass of water. It can be taken with or without food, and patients should follow the dosing schedule prescribed by their healthcare professional to achieve consistent symptom control.

While generally safe, Levocetirizine can cause rare but serious adverse events such as angioedema, anaphylaxis, severe skin reactions (e.g., Stevens‑Johnson syndrome), and hepatic enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash with blistering, or signs of liver dysfunction.

Levocetirizine is contraindicated in individuals with known hypersensitivity to levocetirizine or any component of the formulation. Caution is advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications that could increase sedation or affect drug metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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