Product image of Levocetirizine Krka (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Krka

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Krka (Levocetirizine Dihydrochloride)

Levocetirizine Dihydrochloride, the active ingredient in Levocetirizine Krka, is a second‑generation antihistamine presented as an oral dosage form for oral use. It is employed to alleviate symptoms of allergic rhinitis and to manage chronic idiopathic urticaria in adults and adolescents. It offers a non‑sedating option and conforms to EU‑approved pharmaceutical standards.

GNH India supplies Levocetirizine Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory compliance across all markets, with reliable logistics and dedicated customer support.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levocetirizine Krka, a second‑generation antihistamine, is used to treat allergic conditions by blocking peripheral H1 receptors.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Seasonal allergic rhinitis: provides symptom relief during pollen exposure periods.
  • Chronic idiopathic urticaria: decreases the frequency and severity of hives and associated itching.

How It Works

  • Levocetirizine Dihydrochloride selectively binds to peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation. By inhibiting this receptor activity, the drug reduces the typical allergic symptoms such as itching, swelling, and nasal discharge without readily crossing the blood‑brain barrier, thereby minimizing central nervous system effects.

Side Effects

Levocetirizine Krka may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Drowsiness: mild sleepiness reported by some patients.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivary flow.
  • Fatigue: general lack of energy.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or tongue requiring urgent care.
  • Anaphylaxis: severe allergic reaction with possible respiratory compromise.
  • Stevens‑Johnson syndrome: rare skin blistering condition.
  • Thrombocytopenia: low platelet count observed in isolated cases.
  • Cardiac arrhythmia: irregular heartbeat reported infrequently.

Precautions & Warnings

Before prescribing Levocetirizine Krka, clinicians should consider several precautionary measures to ensure patient safety.

  • Pregnancy: assess risk‑benefit and consult obstetric guidance.
  • Breastfeeding: monitor infant for possible sedation or allergic reactions.
  • Renal impairment: dose adjustment may be required in severe dysfunction.
  • Concomitant CNS depressants: avoid additive sedation when combined with alcohol or sedatives.
  • Elderly patients: start with lowest effective dose and monitor for side effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging and protect from moisture.

Avoid Interactions

Levocetirizine Krka can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Alcohol: may enhance sedative effects.
  • Other H1 antihistamines: additive antihistaminic activity can increase drowsiness.
  • Ketoconazole: strong CYP3A4 inhibition may raise levocetirizine plasma levels.

Moderate Interactions (Monitor Closely)

  • Erythromycin: moderate CYP3A4 inhibitor that can modestly increase drug exposure.
  • Cimetidine: may reduce renal clearance, leading to higher concentrations.
  • Theophylline: potential for increased theophylline levels.
  • Ritonavir: may elevate levocetirizine concentrations.

Frequently Asked Questions

Levocetirizine Krka is indicated for the symptomatic relief of allergic rhinitis, including seasonal and perennial forms, and for the treatment of chronic idiopathic urticaria. By reducing histamine‑mediated responses, it helps alleviate nasal congestion, sneezing, itching, and the appearance of hives.

Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and triggering the cascade that causes vasodilation, increased vascular permeability, and nerve stimulation. This inhibition reduces the classic allergic signs such as itching, swelling, and nasal discharge while limiting central nervous system penetration.

The appropriate dose of Levocetirizine Krka is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, and renal function. The prescriber will select the strength and dosing schedule that best matches the individual therapeutic need.

Safety data for Levocetirizine during pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks and consider alternative treatments when appropriate. Breastfeeding mothers should monitor the infant for any signs of sedation or allergic reactions.

To place an order, submit an enquiry on the Levocetirizine Krka product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is the active enantiomer of cetirizine, offering similar efficacy with a lower incidence of sedation for many patients. Compared with first‑generation antihistamines, it provides more selective H1 blockade and fewer anticholinergic side effects, making it a preferred option for chronic use.

Levocetirizine Krka should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or extreme heat.

Levocetirizine Krka is administered orally, typically as a tablet taken with or without food. The exact method of intake, including whether to swallow whole or with water, is outlined by the prescribing clinician and should be followed as directed.

Serious adverse reactions, although rare, include angioedema, anaphylaxis, Stevens‑Johnson syndrome, thrombocytopenia, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, severe skin reactions, unexplained bruising, or irregular heartbeats.

Levocetirizine Krka is contraindicated in individuals with known hypersensitivity to levocetirizine, other antihistamines, or any of the product’s excipients. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking medications that can significantly increase its plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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