Product image of Levocetirizine Urgo (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Urgo

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Urgo (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Levocetirizine Urgo, is a second‑generation antihistamine presented as an oral dosage form for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in adults and children.

GNH India supplies Levocetirizine Urgo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for global distribution. It offers reliable sourcing and logistical support across multiple regions.

Manufacturer / TM Owner

Laboratoires Urgo Healthcare

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Indications & Clinical Uses

Levocetirizine is used to manage allergic conditions by blocking peripheral H1 receptors.

  • Allergic rhinitis (seasonal and perennial): reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: decreases frequency and severity of hives and itching.
  • Allergic conjunctivitis: helps relieve eye itching and redness.

How It Works

  • Levocetirizine acts as a highly selective antagonist of peripheral histamine H1 receptors. By binding to these receptors, it prevents histamine‑mediated cellular responses that cause vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the typical signs and symptoms of allergic reactions without significant central nervous system penetration.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness: mild to moderate sedation, especially at treatment initiation.
  • Fatigue: feeling of reduced energy.
  • Dry mouth: decreased salivation.
  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Abdominal discomfort: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, or tongue requiring urgent care.
  • Anaphylaxis: severe, life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.
  • Tachycardia: rapid heart rate.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Neutropenia: reduced white blood cell count.

Precautions & Warnings

When prescribing or dispensing Levocetirizine, consider the following safety measures.

  • Avoid driving if drowsy: monitor for sedation, especially during the first days of therapy.
  • Use with caution in renal impairment: dose adjustment may be required in patients with reduced kidney function.
  • Avoid concomitant alcohol: alcohol can potentiate central nervous system depression.
  • Do not use in known hypersensitivity: contraindicated for patients allergic to levocetirizine or other piperazine antihistamines.
  • Pregnancy and lactation: consult a healthcare professional before use; benefits must outweigh potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levocetirizine may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Alcohol: may potentiate central nervous system depression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): can increase levocetirine plasma concentrations.
  • Other antihistamines: additive antihistaminic effects may increase sedation.

Moderate Interactions (Monitor Closely)

  • Theophylline: levocetirine may raise theophylline levels.
  • CNS depressants (benzodiazepines, opioids): combined use can enhance sedation.
  • Anticholinergic agents: may worsen dry mouth and other anticholinergic side effects.

Frequently Asked Questions

Levocetirizine Urgo is an oral antihistamine indicated for the relief of symptoms associated with allergic rhinitis, such as sneezing, nasal congestion, and itching, as well as for the management of chronic idiopathic urticaria, helping to reduce the frequency and severity of hives and related itching.

Levocetirizine works by selectively blocking peripheral histamine H1 receptors. This antagonism prevents histamine from binding to its receptors, thereby inhibiting the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation, which are responsible for typical allergic symptoms.

The exact dose of Levocetirizine Urgo is determined by a qualified healthcare professional based on the patient’s age, condition, and clinical response. In many adult patients, a common regimen is 5 mg taken once daily, but the prescriber may adjust the dose as needed.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the Levocetirizine Urgo product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levocetirine is a second‑generation antihistamine, offering effective H1‑receptor blockade with a lower propensity for sedation compared with first‑generation agents such as diphenhydramine. Its rapid onset and once‑daily dosing make it convenient, while its selectivity reduces anticholinergic side effects, providing an advantage for patients who need daytime symptom control.

Levocetirizine Urgo should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Levocetirizine Urgo is taken orally, usually as a tablet or film‑coated tablet, with or without food. Swallow the tablet whole with a glass of water. The dosage schedule and any specific administration instructions are provided by the prescribing clinician.

Although rare, serious adverse reactions can include angioedema, anaphylactic shock, severe skin reactions such as Stevens‑Johnson syndrome, and significant cardiac effects like tachycardia. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash that spreads rapidly, or any signs of an allergic emergency.

Levocetirizine Urgo should not be used by individuals with a known hypersensitivity to levocetirine, its salts, or other piperazine‑type antihistamines. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and it should be avoided in those with a history of severe allergic reactions unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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