Product image of Levocetirizine Viatris (Levocetirizine Dihydrochloride) supplied by GNH India

Levocetirizine Viatris

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Levocetirizine Viatris (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Levocetirizine Viatris, is a second‑generation antihistamine presented as an oral tablet for oral use. It is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.

GNH India supplies Levocetirizine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

  • Levocetirizine acts as a selective peripheral H1‑receptor antagonist to manage allergic conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Seasonal allergic rhinitis: provides symptom control during pollen seasons.
  • Chronic idiopathic urticaria: alleviates wheals and itching associated with chronic hives.

How It Works

  • Levocetirizine dihydrochloride selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this pathway, it reduces the classic signs of allergic inflammation without readily crossing the blood‑brain barrier, which limits central nervous system effects.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation
  • Headache
  • Dry mouth
  • Fatigue
  • Nausea
  • Abdominal discomfort

Serious or Rare Side Effects

  • Angioedema or swelling of the face, lips, tongue
  • Anaphylactic reactions
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Tachycardia or palpitations
  • Hepatic enzyme elevations
  • Hematologic abnormalities (e.g., neutropenia, thrombocytopenia)

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Renal impairment: dose may require adjustment in severe renal dysfunction.
  • Hepatic impairment: use with caution; monitor liver function tests.
  • Elderly patients: increased sensitivity to sedation; monitor for falls.
  • Pregnancy and lactation: safety not fully established; discuss risks with a healthcare professional.
  • Driving or operating machinery: may cause drowsiness; avoid hazardous tasks until individual response is known.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Levocetirizine may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression.
  • CNS depressants (e.g., benzodiazepines, opioids): increased sedation.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise levocetirizine plasma levels.

Moderate Interactions (Monitor Closely)

  • Theophylline: potential increase in theophylline concentrations.
  • Ritonavir or other protease inhibitors: may elevate levocetirizine exposure.
  • Concurrent antihistamines: risk of cumulative anticholinergic effects.

Frequently Asked Questions

Levocetirizine Viatris is prescribed to relieve symptoms of allergic rhinitis, such as sneezing, runny nose, and itching, as well as to control chronic idiopathic urticaria (hives) by reducing wheals and itching. It belongs to the second‑generation antihistamine class, which targets peripheral H1 receptors.

Levocetirizine works by selectively blocking peripheral H1 histamine receptors. This prevents histamine released during allergic reactions from binding to its receptors, thereby reducing vasodilation, increased vascular permeability, and sensory nerve activation that cause typical allergy symptoms.

The exact dose is determined by the prescribing healthcare professional based on the patient’s age, clinical condition, and renal function. In many regions, the standard adult regimen is one tablet taken once daily, but the prescriber may adjust the dose as needed.

Safety data for Levocetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levocetirizine is a second‑generation antihistamine, offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents like diphenhydramine. Compared with cetirizine, its enantiomer, levocetirizine may provide similar efficacy at a lower dose and slightly reduced drowsiness, though individual responses vary.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use. Do not store in a refrigerator or freezer.

Levocetirizine Viatris is taken orally, usually as a tablet. It should be swallowed whole with a glass of water. The medication can be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any specific dietary considerations.

While rare, serious adverse events include angioedema, anaphylactic reactions, severe skin reactions such as Stevens‑Johnson syndrome, and significant hepatic enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or signs of liver dysfunction.

Levocetirizine should be avoided in individuals with known hypersensitivity to levocetirizine, cetirizine, or any component of the formulation. Caution is also advised for patients with severe renal impairment, as dose adjustment may be required, and for those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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