Product image of Levodolevodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodolevodopa/Carbidopa/Entacapone Teva

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodolevodopa/Carbidopa/Entacapone Teva (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodolevodopa/Carbidopa/Entacapone Teva, is a Levodopa/Carbidopa/Entacapone combination presented as a tablet (strength not specified) for oral use. It treats the motor symptoms of Parkinson's disease in adult patients.
GNH India supplies Levodolevodopa/Carbidopa/Entacapone Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Italia S.R.L.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease and related motor fluctuation pathways.

  • Parkinson's disease (motor fluctuations): reduces OFF periods and improves overall motor control.
  • Parkinson's disease (adjunct to levodopa): enhances central levodopa availability and prolongs its therapeutic effect.
  • Parkinson's disease (advanced stage): helps control symptoms when standard levodopa therapy alone is insufficient.

How It Works

  • Levodopa is absorbed and crosses the blood‑brain barrier where it is decarboxylated to dopamine, restoring deficient neurotransmission. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism, extending its plasma half‑life and enhancing dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Orthostatic hypotension
  • Dizziness
  • Insomnia
  • Dyskinesia

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Severe hypertension or hypotension
  • Hallucinations or psychosis
  • Severe depression or suicidal thoughts
  • Hepatic dysfunction
  • Allergic skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension, especially at therapy initiation.
  • Assess psychiatric status: be alert for hallucinations, confusion, or mood changes.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Avoid abrupt discontinuation: taper to prevent withdrawal symptoms.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may exacerbate central side effects.
  • Iron or calcium supplements: reduce levodopa absorption if taken simultaneously.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Antihypertensive drugs: additive hypotensive effect.
  • Other COMT inhibitors: increased risk of toxicity.

Frequently Asked Questions

Levodolevodopa/Carbidopa/Entacapone Teva is a prescription oral medication indicated for the treatment of Parkinson's disease. It is used to improve motor symptoms and reduce OFF periods in patients who experience fluctuations in response to levodopa therapy.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system. Entacapone inhibits the COMT enzyme, slowing levodopa breakdown and extending its therapeutic effect.

The appropriate dose is individualized and determined by the prescribing physician based on the patient’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control.

Safety data in pregnancy and lactation are limited. The product should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa/Carbidopa/Entacapone combines three mechanisms—dopamine precursor, peripheral decarboxylase inhibition, and COMT inhibition—offering more consistent levodopa levels than levodopa alone. Compared with other combinations, it provides a convenient single tablet that may reduce dosing frequency and improve symptom control.

Store the tablets at room temperature, below 25 °C, in the original container. Protect them from moisture, heat and direct sunlight to maintain stability and potency throughout the shelf life.

The medication is taken orally, usually with food or as directed by the prescriber, to minimize gastrointestinal discomfort. Tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed.

Serious adverse events can include neuroleptic malignant syndrome, severe hypertension or hypotension, hallucinations, severe depression or suicidal thoughts, and rare but life‑threatening skin reactions. Patients should be monitored closely for any of these signs.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid this product. It is also contraindicated in individuals taking non‑selective MAO inhibitors or those with severe hepatic impairment without physician supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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