Product image of Levodonna (Levonorgestrel) supplied by GNH India

Levodonna

Active Ingredient:
Levonorgestrel
Origin:
EU

Levodonna (Levonorgestrel)

Levonorgestrel, the active ingredient in Levodonna, is a synthetic progestin presented as an oral tablet formulation for oral use. It is employed to prevent pregnancy after unprotected intercourse and as a regular contraceptive method, acting on hormonal pathways that inhibit ovulation and alter the uterine lining.

GNH India supplies Levodonna as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing standards and reliable global distribution.

Manufacturer / TM Owner

Sandoz A/S

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Indications & Clinical Uses

Levonorgestrel is a progestin used in hormonal contraception.

  • Emergency contraception: prevents pregnancy when taken shortly after unprotected sexual activity.
  • Pregnancy prevention: used as part of contraceptive regimens to inhibit ovulation and implantation.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge required for ovulation. It also thickens cervical mucus, reducing sperm penetration, and induces changes in the endometrial lining that make implantation unlikely. The combined actions provide rapid contraceptive effect when administered within the recommended time frame.

Side Effects

Levodonna may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Abdominal pain
  • Menstrual irregularities

Serious or Rare Side Effects

  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)
  • Severe allergic reaction (anaphylaxis)
  • Liver dysfunction
  • Ectopic pregnancy (if pregnancy occurs despite use)

Precautions & Warnings

Before using Levodonna, certain precautions should be considered to ensure safety.

  • Contraindicated in pregnancy: do not use if already pregnant.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution in liver disease: assess hepatic function before prescribing.
  • Assess thromboembolic risk: avoid in women with active clotting disorders.
  • Interact with enzyme inducers: review concomitant medications.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Levodonna can interact with other medicines, affecting its effectiveness or safety.

Major Interactions (Avoid)

  • Rifampicin and other strong enzyme inducers: reduce levonorgestrel levels.
  • Anticonvulsants such as phenytoin or carbamazepine: may decrease contraceptive efficacy.
  • St. John’s wort: herbal inducer that lowers drug exposure.

Moderate Interactions (Monitor Closely)

  • Antifungal agents like ketoconazole: may increase levonorgestrel concentrations.
  • Certain antiretrovirals (e.g., ritonavir): can alter hormone metabolism.
  • Antibiotics such as rifabutin: may have modest effect on efficacy.

Frequently Asked Questions

Levodonna contains levonorgestrel, a progestin used as an emergency contraceptive to prevent pregnancy after unprotected intercourse and as a regular method of pregnancy prevention in certain contraceptive regimens. It works by inhibiting ovulation and altering the uterine lining.

Levonorgestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge needed for ovulation. It also thickens cervical mucus and modifies the endometrial lining, reducing the likelihood of fertilization and implantation.

The specific dose and regimen of Levodonna are determined by the prescribing healthcare professional based on the indication, timing of administration, and patient factors. Patients should follow the prescriber’s instructions and the product labeling.

Levodonna is intended to prevent pregnancy and is not recommended for use during an established pregnancy. Its safety during breastfeeding has not been fully established; women should consult their healthcare provider before using it while nursing.

To place an order, submit an enquiry on the Levodonna product page at gnhindia.com, providing the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then responds with pricing, availability, shipping details, and any necessary import documentation.

Levodonna’s active ingredient, levonorgestrel, is a widely used progestin in emergency contraception, offering efficacy when taken within 72 hours of unprotected intercourse. Compared with ulipristal acetate, another option, levonorgestrel is generally less effective the longer the delay but is available over‑the‑counter in many regions.

Levodonna should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date.

Levodonna is taken orally, usually as a single tablet or as directed by a healthcare professional. The tablet should be swallowed with water and taken as soon as possible after unprotected sexual activity for optimal effectiveness.

Although rare, serious adverse events can include thromboembolic disorders, severe allergic reactions such as anaphylaxis, and liver dysfunction. Patients experiencing symptoms like unexplained swelling, severe abdominal pain, rash, or breathing difficulties should seek immediate medical attention.

Levodonna is contraindicated in women who are pregnant, have a known hypersensitivity to levonorgestrel or any excipients, have active or a history of thromboembolic disease, severe liver disease, or undiagnosed abnormal vaginal bleeding. Consultation with a healthcare provider is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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