Product image of Levodonna (Levonorgestrel) supplied by GNH India

Levodonna

Active Ingredient:
Levonorgestrel
Origin:
EU

Levodonna (Levonorgestrel)

Levonorgestrel, the active ingredient in Levodonna, is a progestin presented as an oral tablet for systemic use. It works by inhibiting or delaying ovulation and may alter endometrial receptivity, providing a pharmacological option for emergency contraception after unprotected sexual contact. It is indicated for use within a limited time window following intercourse and is part of established guidelines for post‑coital contraception.

GNH India supplies Levodonna as a licensed, GMP‑qualified product through a GDP‑compliant supply chain, serving hospitals, pharmacies and clinics worldwide with reliable international distribution.

Manufacturer / TM Owner

Sandoz A/S

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Indications & Clinical Uses

Levonorgestrel is a progestin used in the hormonal pathway of contraception.

  • Emergency contraception: prevents pregnancy after unprotected intercourse when taken within the recommended time frame.
  • Hormonal contraception (combined regimens): contributes to contraceptive efficacy as part of multi‑component birth‑control pills.
  • Menstrual cycle regulation (off‑label): may be used to adjust the timing of menses in certain clinical situations.

How It Works

  • Levonorgestrel binds to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis, suppressing the luteinizing hormone surge and thereby inhibiting or delaying ovulation. It also induces changes in the cervical mucus and endometrial lining that reduce the likelihood of fertilization and implantation, respectively.

Side Effects

Levodonna may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: occasional tension‑type headache.
  • Fatigue: feeling of tiredness or low energy.
  • Abdominal pain: mild cramps or discomfort.
  • Menstrual changes: spotting or altered bleeding pattern.
  • Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or anaphylaxis.
  • Severe abdominal pain: persistent or worsening pain.
  • Chest pain: may indicate cardiovascular involvement.
  • Thromboembolic events: rare clot formation in veins or arteries.

Precautions & Warnings

Before using Levodonna, consider the following safety measures.

  • Timing of intercourse: ensure the product is taken within the approved window after unprotected sex.
  • Contraindications: avoid if known hypersensitivity to levonorgestrel or other progestins.
  • Medical history: disclose any history of thromboembolic disorders, liver disease, or hormone‑sensitive cancers.
  • Drug interactions: review concurrent use of enzyme‑inducing medications that may reduce efficacy.
  • Repeat use: limit frequent use and discuss long‑term contraceptive options with a healthcare professional.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodonna can interact with several medicines, affecting its effectiveness or safety.

Major Interactions (Avoid)

  • Rifampicin: strong enzyme inducer that markedly reduces levonorgestrel levels.
  • Carbamazepine: induces hepatic metabolism, decreasing efficacy.
  • Phenytoin: accelerates clearance, potentially leading to failure of contraception.
  • St. John's wort: herbal inducer that may lower drug exposure.

Moderate Interactions (Monitor Closely)

  • Ketoconazole: antifungal that can increase levonorgestrel concentrations.
  • Efavirenz: antiretroviral that may modestly reduce effectiveness.
  • Sertraline: antidepressant that could alter hormonal balance, requiring monitoring.

Frequently Asked Questions

Levodonna contains levonorgestrel, a progestin that is used primarily for emergency contraception to prevent pregnancy after unprotected sexual intercourse. It may also be incorporated into certain hormonal birth‑control regimens and, in some cases, employed off‑label to help regulate menstrual timing.

Levonorgestrel binds to progesterone receptors, suppressing the luteinizing hormone surge that triggers ovulation. By delaying or inhibiting ovulation and altering cervical mucus and endometrial receptivity, it reduces the chances of fertilization and implantation, providing effective post‑coital contraception when taken promptly.

The specific dose and regimen of Levodonna are determined by the prescribing healthcare professional based on the timing of intercourse and individual patient factors. Patients should follow the exact instructions provided by their prescriber and not alter the dose on their own.

Levodonna is intended for use after unprotected intercourse to prevent pregnancy and is not meant for ongoing use during an established pregnancy. Limited data are available for breastfeeding; however, the amount excreted in breast milk is considered low. Women should discuss any concerns with their healthcare provider.

To place an order, submit an enquiry on the Levodonna product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Levodonna (levonorgestrel) is a single‑dose progestin that works by delaying ovulation, similar to other levonorgestrel‑based emergency pills. Compared with ulipristal acetate, another oral emergency contraceptive, levonorgestrel is generally less effective when taken beyond 72 hours after intercourse but has a well‑established safety profile and is widely available in many markets.

Levodonna should be stored at room temperature, below 25 °C (77 °F). Keep the tablets in the original blister pack or container, protect them from moisture, excessive heat and direct sunlight. Do not use the product after the expiration date printed on the packaging.

Levodonna is taken orally, usually as a single tablet taken as soon as possible after unprotected sexual contact. The tablet should be swallowed whole with water and not chewed or broken. Follow the prescriber’s instructions regarding timing relative to the event.

Serious but rare risks include severe allergic reactions such as anaphylaxis, chest pain that could indicate cardiovascular issues, and rare thromboembolic events. Patients experiencing any signs of a severe reaction—such as difficulty breathing, swelling of the face or throat, persistent chest pain, or unexplained leg swelling—should seek immediate medical attention.

Levodonna should be avoided by individuals with a known hypersensitivity to levonorgestrel or any component of the tablet, those who are already pregnant, and patients with a history of thromboembolic disorders, severe liver disease, or hormone‑sensitive cancers unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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