Product image of Levodopa/Benserazid Ratiopharm (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Levodopa/Benserazid Ratiopharm

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Levodopa/Benserazid Ratiopharm (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredient in Levodopa/Benserazid Ratiopharm, is a dopamine precursor and dopa decarboxylase inhibitor presented as an oral tablet for oral use. It treats Parkinson's disease in adult patients by improving motor function.

GNH India supplies Levodopa/Benserazid Ratiopharm as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Levodopa/Benserazide is used in the management of Parkinsonian disorders, targeting dopaminergic deficiency.

  • Parkinson's disease: reduces rigidity, tremor and bradykinesia, improving overall motor performance.

How It Works

  • Levodopa is absorbed from the gastrointestinal tract and crosses the blood‑brain barrier, where aromatic L‑amino‑acid decarboxylase converts it to dopamine. Benserazide, a peripheral dopa decarboxylase inhibitor, does not cross the barrier and prevents peripheral conversion, thereby increasing the amount of levodopa that reaches the central nervous system and enhancing dopaminergic neurotransmission.

Side Effects

Levodopa/Benserazide may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Headache
  • Insomnia
  • Dry mouth

Serious or Rare Side Effects

  • Dyskinesia (involuntary movements)
  • Severe psychiatric disturbances (hallucinations, confusion)
  • Cardiac arrhythmias or severe hypotension
  • Neuroleptic malignant‑like syndrome
  • Hyperpyrexia with muscle rigidity

Precautions & Warnings

Levodopa/Benserazide requires careful monitoring to minimise risks.

  • Monitor blood pressure: watch for orthostatic hypotension.
  • Assess liver function: adjust use in hepatic impairment.
  • Avoid abrupt discontinuation: risk of withdrawal syndrome.
  • Use with caution in elderly patients: increased fall risk.
  • Avoid concomitant non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Levodopa/Benserazide interacts with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may cause hypertensive crisis.
  • Anticholinergic agents: may reduce antiparkinson efficacy.
  • Certain antihypertensives: may exacerbate hypotension.

Moderate Interactions (Monitor Closely)

  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Iron or calcium supplements: may decrease levodopa absorption.
  • CNS depressants: may enhance sedation or dizziness.

Frequently Asked Questions

Levodopa/Benserazide is prescribed to manage the motor symptoms of Parkinson's disease, such as tremor, rigidity, and bradykinesia, by restoring dopamine levels in the brain.

Levodopa is converted to dopamine after crossing the blood‑brain barrier, while benserazide blocks peripheral conversion of levodopa, ensuring more of the active compound reaches the central nervous system.

The appropriate dose is individualized by the prescribing clinician based on disease severity, patient response, and tolerability; no fixed regimen is provided here.

Safety data are limited; the product should be used only if the potential benefit outweighs the risk, and it is generally avoided during pregnancy and lactation unless absolutely necessary.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Levodopa/Benserazide is similar to the levodopa/carbidopa combination, both pairing levodopa with a peripheral decarboxylase inhibitor. The choice often depends on regional availability, patient tolerance and physician preference.

Store the tablets at room temperature, below 25 °C, in the original packaging, protected from moisture and direct sunlight to maintain stability.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals helps maintain stable absorption.

Serious concerns include the development of dyskinesias, severe psychiatric effects such as hallucinations, and marked hypotension that can lead to fainting or cardiovascular complications.

Patients with known hypersensitivity to levodopa or benserazide, those with narrow‑angle glaucoma, or individuals taking non‑selective MAO inhibitors should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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