Product image of Levodopa-Benserazid Teva (Benserazide, Levodopa) supplied by GNH India

Levodopa-Benserazid Teva

Active Ingredient:
Benserazide, Levodopa
Origin:
EU

Levodopa-Benserazid Teva (Benserazide, Levodopa)

Levodopa, the active ingredient in Levodopa-Benserazid Teva, is an antiparkinson agent presented as an oral tablet for oral use. It is combined with benserazide to increase central dopamine availability and is indicated for the treatment of Parkinson's disease symptoms in adult patients.

GNH India supplies Levodopa-Benserazid Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality through stringent manufacturing standards and regulatory compliance across EU markets.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Levodopa/benserazide is used in the management of Parkinsonian disorders, targeting dopaminergic deficiency.

  • Parkinson's disease: reduces motor symptoms such as bradykinesia, rigidity, and tremor.
  • Early-stage Parkinson's disease: improves initial motor function and delays progression of symptoms.
  • Advanced Parkinson's disease with motor fluctuations: smooths out on‑off periods and enhances overall mobility.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopaminergic transmission. Benserazide, a peripheral dopa‑decarboxylase inhibitor, prevents premature conversion of levodopa outside the brain, thereby increasing the amount of levodopa that reaches the central nervous system for conversion to dopamine.

Side Effects

Levodopa/benserazide may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea
  • Vomiting
  • Orthostatic hypotension
  • Dizziness
  • Headache

Serious or Rare Side Effects

  • Dyskinesia (involuntary movements)
  • Hallucinations or psychosis
  • Severe hypotension
  • Cardiac arrhythmias
  • Anaphylactic reactions

Precautions & Warnings

When prescribing Levodopa/benserazide, several precautions should be observed to ensure safe use.

  • Dose titration: start low and increase gradually to minimize gastrointestinal side effects.
  • Cardiovascular monitoring: watch for orthostatic hypotension and arrhythmias.
  • Psychiatric monitoring: assess for hallucinations or mood changes.
  • Renal/hepatic impairment: adjust dosing in patients with significant organ dysfunction.
  • Concomitant MAO‑B inhibitors: avoid or use with caution due to increased levodopa levels.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa/benserazide can interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors (e.g., phenelzine): risk of hypertensive crisis.
  • Dopamine antagonists (e.g., typical antipsychotics): may reduce therapeutic effect.
  • Iron or calcium supplements taken simultaneously: decrease levodopa absorption.

Moderate Interactions (Monitor Closely)

  • Selective MAO‑B inhibitors (e.g., selegiline): may increase levodopa plasma levels.
  • Anticholinergic agents: can enhance central side effects.
  • Antihypertensive drugs: additive blood pressure‑lowering effect.
  • SSRIs or SNRIs: monitor for serotonin syndrome risk.

Frequently Asked Questions

Levodopa‑Benserazid Teva is indicated for the treatment of Parkinson's disease. It helps alleviate motor symptoms such as bradykinesia, rigidity, and tremor by restoring dopamine levels in the brain.

Levodopa is a precursor of dopamine that crosses the blood‑brain barrier. Once inside the central nervous system it is converted to dopamine, compensating for the loss of dopaminergic neurons characteristic of Parkinson's disease.

The appropriate dose is individualized by the prescribing clinician based on disease severity, patient response, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control while minimizing side effects.

Safety in pregnancy and lactation has not been established. The medication should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and required import documentation.

Levodopa/benserazide provides direct dopamine replacement, whereas dopamine agonists stimulate dopamine receptors. Levodopa generally offers stronger symptom relief but may be associated with motor complications over time, while agonists have a lower risk of dyskinesia but can cause other side effects such as somnolence.

Store the product at ambient temperature below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Do not refrigerate or freeze the tablets.

The medication is taken orally as a tablet, usually with a glass of water. It may be taken with or without food, but taking it with a light meal can reduce gastrointestinal irritation.

Serious adverse events include dyskinesia (involuntary movements), hallucinations or psychosis, severe hypotension, cardiac arrhythmias, and rare anaphylactic reactions. Patients should be monitored closely for these effects, especially during dose escalation.

The drug is contraindicated in patients with known hypersensitivity to levodopa or benserazide, those with narrow‑angle glaucoma, severe cardiovascular disease, or uncontrolled psychiatric disorders. Caution is also advised for individuals with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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