Product image of Levodopa/Benserazide Orifarm (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Levodopa/Benserazide Orifarm

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Levodopa/Benserazide Orifarm (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredient in Levodopa/Benserazide Orifarm, is a Levodopa/benserazide combination presented as an oral tablet for oral use. It is employed to manage motor symptoms of Parkinson's disease in adult patients.
GNH India supplies Levodopa/Benserazide Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Levodopa/Benserazide is used within the antiparkinson therapeutic pathway to improve dopaminergic activity.

  • Parkinson's disease: reduces bradykinesia, rigidity and tremor, improving motor function.
  • Parkinsonian syndrome: alleviates motor deficits associated with secondary Parkinsonism.
  • Rest tremor: diminishes amplitude and frequency of resting tremor in affected individuals.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopaminergic transmission. Benserazide, a peripheral aromatic L‑amino acid decarboxylase inhibitor, blocks levodopa conversion outside the brain, increasing its central availability and minimizing peripheral side effects such as nausea.

Side Effects

Levodopa/Benserazide may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional emesis, especially after dose initiation.
  • Dizziness: often related to orthostatic changes.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Hallucinations: visual or auditory perceptual disturbances.
  • Severe hypotension: marked blood pressure reduction requiring medical attention.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible patients.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe psychiatric symptoms: agitation, confusion or psychosis.

Precautions & Warnings

When prescribing Levodopa/Benserazide, clinicians should consider several safety measures.

  • Dose titration: start low and increase gradually to minimize adverse effects.
  • Monitor blood pressure: watch for orthostatic hypotension, especially in the elderly.
  • Assess psychiatric status: the drug may exacerbate hallucinations or confusion.
  • Avoid abrupt discontinuation: sudden stop can lead to withdrawal and worsening of Parkinsonian signs.
  • Use with caution in renal or hepatic impairment: adjust therapy based on organ function.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Benserazide interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): antagonize dopamine effect, reducing therapeutic benefit.
  • Pyridoxine (vitamin B6): enhances peripheral decarboxylation, decreasing central levodopa levels.
  • High‑protein meals: compete for intestinal transport, lowering levodopa absorption.
  • Iron or calcium supplements: chelate levodopa, reducing bioavailability.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect may require dose adjustment.
  • SSRIs or SNRIs: potential for serotonin syndrome when combined with MAO‑B inhibitors.
  • Diuretics: may affect electrolyte balance, influencing blood pressure control.

Frequently Asked Questions

Levodopa/Benserazide Orifarm is an oral antiparkinson medication that combines levodopa with the peripheral decarboxylase inhibitor benserazide. It is prescribed to improve motor symptoms such as bradykinesia, rigidity, and resting tremor in patients diagnosed with Parkinson's disease.

Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine, replenishing deficient central dopaminergic pathways. Benserazide inhibits the enzyme aromatic L‑amino acid decarboxylase outside the brain, preventing premature conversion of levodopa and thereby increasing the amount that reaches the central nervous system.

The specific dose and dosing schedule of Levodopa/Benserazide Orifarm are individualized by the prescribing healthcare professional based on disease severity, patient age, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Levodopa/Benserazide in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant. Clinicians typically evaluate each case carefully and may consider alternative therapies when possible.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Levodopa/Benserazide is a standard levodopa‑based therapy that offers rapid symptomatic relief. Compared with dopamine agonists, it generally provides stronger motor improvement but may be associated with more motor complications over time. Unlike mono‑therapy levodopa, the benserazide component reduces peripheral side effects, making the combination a common first‑line choice.

Store the tablets at room temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Levodopa/Benserazide Orifarm is taken orally, usually with a glass of water. It may be administered with or without food, but high‑protein meals can interfere with absorption, so clinicians often advise spacing the dose from protein‑rich meals.

Serious risks include dyskinesia (involuntary movements), hallucinations or psychosis, severe orthostatic hypotension, and rare but life‑threatening conditions such as neuroleptic malignant syndrome. Patients should be monitored regularly for these events, and any sudden changes should prompt medical evaluation.

Patients with known hypersensitivity to levodopa, benserazide, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors due to the risk of hypertensive crisis, and caution is advised in those with severe cardiovascular disease, uncontrolled psychiatric disorders, or significant renal/hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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