Product image of Levodopa Benserazide Teva (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Levodopa Benserazide Teva

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Levodopa Benserazide Teva (Benserazide Hydrochloride, Levodopa)

Levodopa and Benserazide, the active ingredient in Levodopa Benserazide Teva, is an antiparkinson agent presented as an oral tablet for oral use. It is employed to manage the motor symptoms of Parkinson's disease and related Parkinsonian syndromes in adult patients.

GNH India supplies Levodopa Benserazide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards, provides regulatory documentation, and offers reliable logistics for global distribution. Customers benefit from consistent supply and technical support.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Levodopa + Benserazide is used in the management of Parkinsonian disorders, acting on central dopaminergic pathways.

  • Parkinson's disease: improves motor function, reduces rigidity and bradykinesia.
  • Parkinsonian syndrome: alleviates symptoms caused by drug‑induced or secondary Parkinsonism.
  • Rest tremor: diminishes tremor amplitude and frequency.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine, restoring deficient central dopaminergic transmission. Benserazide, a peripheral aromatic L‑amino acid decarboxylase inhibitor, blocks levodopa conversion outside the brain, increasing the amount of levodopa that reaches the central nervous system and enhancing its therapeutic effect.

Side Effects

Levodopa + Benserazide may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating sleep.
  • Dry mouth: reduced salivation.
  • Dyspepsia: indigestion or stomach discomfort.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: marked blood pressure drop.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Neuroleptic malignant syndrome: rare life‑threatening reaction.

Precautions & Warnings

When prescribing Levodopa + Benserazide, clinicians should consider several safety measures.

  • Dose titration: start low and increase gradually to minimize side effects.
  • Monitor blood pressure: watch for orthostatic hypotension, especially in the elderly.
  • Assess hepatic and renal function: adjust dosing if impairment is present.
  • Avoid abrupt discontinuation: taper to prevent withdrawal symptoms.
  • Use with caution in cardiac disease: risk of arrhythmias may be increased.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa + Benserazide can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may cause hypertensive crisis.
  • Anticholinergic agents: can reduce antiparkinson efficacy.
  • Pyridoxine (vitamin B6): enhances peripheral levodopa metabolism, lowering central availability.
  • CNS depressants: additive sedation and dizziness.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may potentiate orthostatic hypotension.
  • Iron or calcium supplements: can decrease levodopa absorption.
  • High‑protein meals: compete for transport, reducing drug uptake.

Frequently Asked Questions

Levodopa Benserazide Teva is an antiparkinson medication indicated for the treatment of Parkinson's disease and Parkinsonian syndromes. It helps improve motor symptoms such as rigidity, bradykinesia, and tremor by restoring dopamine levels in the brain.

Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine, compensating for the loss of dopaminergic neurons. Benserazide inhibits peripheral aromatic L‑amino acid decarboxylase, preventing levodopa from being metabolized outside the brain, thereby increasing its central availability.

The specific dose and dosing schedule are determined by the prescribing physician based on the individual patient's clinical condition, response, and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control while minimizing side effects.

Safety data for use in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa combined with benserazide is considered the most effective oral therapy for symptomatic control of Parkinson's disease. Compared with dopamine agonists, it often provides stronger motor improvement but may have a higher incidence of motor complications such as dyskinesia. The choice depends on disease stage, patient age, and tolerance.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture and direct sunlight to maintain stability and potency throughout the shelf life.

Levodopa Benserazide Teva is taken orally, usually with a glass of water. It may be administered with or without food, but high‑protein meals can affect absorption, so patients are often advised to take the medication at consistent times relative to meals.

Serious risks include the development of dyskinesia (involuntary movements), hallucinations, severe orthostatic hypotension, and rare neuroleptic malignant syndrome. Patients should be monitored regularly for these events, and any sudden changes in mental status or motor function should be reported promptly.

Patients with known hypersensitivity to levodopa, benserazide, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors. Caution is advised in patients with severe cardiac disease, uncontrolled hypertension, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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