Product image of Levodopa/Benserazide Teva Uk (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Levodopa/Benserazide Teva Uk

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Levodopa/Benserazide Teva Uk (Benserazide Hydrochloride, Levodopa)

Levodopa, the active ingredient in Levodopa/Benserazide Teva Uk, is an antiparkinson agent presented as an oral tablet for oral use. It is used to treat Parkinson's disease in adult patients by replenishing central dopamine levels.
GNH India supplies Levodopa/Benserazide Teva Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

Levodopa/Benserazide is indicated for disorders of the dopaminergic system, primarily Parkinson's disease and related conditions.

  • Parkinson's disease: improves motor symptoms such as rigidity, tremor and bradykinesia.
  • Levodopa‑responsive Parkinsonism: restores dopamine deficiency to enhance movement control.
  • Secondary Parkinsonism (e.g., drug‑induced): provides symptomatic relief of motor deficits.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine within the central nervous system, compensating for the loss of endogenous dopamine. Benserazide, a peripheral aromatic L‑amino acid decarboxylase inhibitor, prevents peripheral conversion of levodopa, thereby increasing its availability to the brain and reducing peripheral side effects.

Side Effects

Levodopa/Benserazide may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dyspepsia: indigestion or abdominal discomfort.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Psychiatric disturbances: hallucinations, confusion or depression.
  • Severe hypotension: marked blood pressure drop requiring medical attention.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible individuals.

Precautions & Warnings

When prescribing Levodopa/Benserazide, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic changes, especially at therapy initiation.
  • Assess psychiatric status: be alert for hallucinations or mood alterations.
  • Adjust dose in renal impairment: reduced clearance may increase exposure.
  • Avoid abrupt discontinuation: taper to prevent withdrawal symptoms.
  • Use with caution in elderly patients: increased sensitivity to side effects.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa/Benserazide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Anticholinergic agents: may mask therapeutic response.
  • Iron or calcium supplements: reduce levodopa absorption.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: additive hypotensive effect.
  • SSRIs or SNRIs: potential for serotonin syndrome.
  • High‑protein meals: may diminish levodopa bioavailability.

Frequently Asked Questions

Levodopa/Benserazide is prescribed to manage the motor symptoms of Parkinson's disease and other levodopa‑responsive Parkinsonian disorders. By increasing dopamine levels in the brain, it helps reduce rigidity, tremor, and slowness of movement, improving overall functional ability in affected patients.

Levodopa is a precursor of dopamine that crosses the blood‑brain barrier. Once inside the central nervous system, it is converted to dopamine, compensating for the neurotransmitter loss characteristic of Parkinson's disease. Benserazide blocks peripheral conversion, ensuring more levodopa reaches the brain.

The dosage of Levodopa/Benserazide is individualized and determined by the prescribing clinician based on disease severity, patient response, and tolerability. Patients should follow the specific dosing regimen provided by their healthcare professional and not adjust the dose without medical advice.

The safety of Levodopa/Benserazide in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa/Benserazide is considered the most effective symptomatic therapy for Parkinson's disease because it directly replenishes dopamine. Other classes, such as dopamine agonists or MAO‑B inhibitors, may be used as adjuncts or early‑stage options, but they generally provide less robust motor improvement than the levodopa‑benserazide combination.

Levodopa/Benserazide tablets should be stored at room temperature, below 25 °C, in their original packaging. Keep them away from excess moisture and direct sunlight to maintain product stability throughout its shelf life.

Levodopa/Benserazide is taken orally, usually with a glass of water. It may be recommended to take the medication with food or on an empty stomach depending on the prescriber's guidance, as food can affect absorption.

Serious risks include the development of dyskinesias (involuntary movements), severe hypotension, and psychiatric effects such as hallucinations or confusion. Patients should be monitored regularly for these events, and any sudden changes should be reported to a healthcare professional promptly.

Levodopa/Benserazide is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients in the formulation. It should also be avoided in individuals taking non‑selective MAO inhibitors due to the risk of hypertensive crisis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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