Product image of Levodopa/Carbidopa/Entacapon Abz (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapon Abz

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapon Abz (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, entacapone, the active ingredient in Levodopa/Carbidopa/Entacapon Abz, is an Antiparkinson agent presented as an oral tablet for oral use. It is indicated for Parkinson's disease and for managing motor fluctuations in patients with Parkinson's disease.
GNH India supplies Levodopa/Carbidopa/Entacapon Abz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used within the Parkinson's disease therapeutic pathway to improve motor control and reduce fluctuations.

  • Parkinson's disease: improves overall motor symptoms such as bradykinesia and rigidity.
  • Motor fluctuations in Parkinson's disease: reduces OFF periods and extends ON time.
  • Wearing‑off phenomenon: stabilises dopamine levels to smooth symptom control.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, replenishing deficient central dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism, prolonging its plasma half‑life, and enhancing its clinical effect.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic blood pressure changes.
  • Headache: transient and usually resolves with continued therapy.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements that may be disabling.
  • Hallucinations: visual or auditory disturbances, especially in older patients.
  • Severe hypotension: sudden drop in blood pressure leading to fainting.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially at treatment initiation.
  • Psychiatric assessment: evaluate for hallucinations, confusion, or mood changes.
  • Renal function: adjust dosing in patients with significant renal impairment.
  • Abrupt discontinuation: avoid sudden stop to prevent severe withdrawal symptoms.
  • Elderly patients: start at low dose and titrate slowly due to increased sensitivity.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO‑B inhibitors: risk of hypertensive crisis or severe serotonin syndrome.
  • Non‑selective MAO inhibitors: may precipitate hypertensive emergencies.
  • Antipsychotics (dopamine antagonists): can markedly reduce therapeutic effect.
  • High‑protein meals: compete for transport across the blood‑brain barrier, diminishing levodopa absorption.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive blood‑pressure lowering effect.
  • SSRIs and other serotonergic agents: monitor for serotonin syndrome.
  • Other COMT inhibitors: increased risk of dopaminergic side effects.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapon Abz is prescribed to treat Parkinson's disease and to manage motor fluctuations such as OFF periods in patients who experience variable symptom control.

Levodopa is converted to dopamine in the brain, carbidopa blocks peripheral conversion of levodopa, increasing its central availability, and entacapone inhibits the COMT enzyme, extending levodopa’s plasma half‑life and enhancing its therapeutic effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s disease stage, response, and tolerability. No fixed regimen is provided here.

Safety in pregnancy and lactation has not been established. The product should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made by a qualified healthcare professional.

Enquiries are submitted via the product page at gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects, and entacapone further prolongs levodopa’s action, offering more stable symptom control and reduced dosing frequency than many single‑component regimens.

Store the tablets at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but high‑protein meals can affect absorption, so timing relative to meals should follow the prescriber’s advice.

Serious risks include dyskinesia, hallucinations, severe hypotension, and rare neuroleptic malignant syndrome. Patients should be monitored closely for any sudden changes in movement, mental status, or blood pressure.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors or those with severe cardiovascular disease without careful supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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