Product image of Levodopa/Carbidopa/Entacapon Beta (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapon Beta

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapon Beta (Carbidopa, Entacapone, Levodopa)

Levodopa, Carbidopa, Entacapone, the active ingredients in Levodopa/Carbidopa/Entacapone Beta, are a dopamine precursor with peripheral DOPA decarboxylase inhibition and COMT inhibition presented as an oral tablet for oral use. It treats Parkinson's disease as an adjunct to levodopa therapy in adult patients.

GNH India supplies Levodopa/Carbidopa/Entacapone Beta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Betapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is indicated for Parkinson's disease and related motor complications, acting as an adjunct to levodopa therapy.

  • Parkinson's disease: improves overall motor function when added to levodopa.
  • Motor fluctuations in Parkinson's disease: reduces OFF time and stabilises response.
  • Early-stage Parkinson's disease: enhances the effectiveness of levodopa and delays progression of symptoms.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, restoring deficient central dopamine levels. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its therapeutic duration.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Headache: transient cranial discomfort.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe dyskinesia: uncontrolled involuntary movements.
  • Neuroleptic malignant syndrome: life‑threatening hyperthermia and rigidity.
  • Cardiac arrhythmias: irregular heart rhythms.
  • Hallucinations or psychosis: visual or auditory disturbances.
  • Severe hypotension: marked blood pressure decline requiring medical attention.
  • Hyperthermia: unexplained high body temperature.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood pressure: check for orthostatic changes and treat hypotension.
  • Assess for dyskinesia: observe for involuntary movements during treatment.
  • Review hepatic function: use caution in patients with liver disease.
  • Avoid in narrow‑angle glaucoma: risk of increased intra‑ocular pressure.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may precipitate hypertensive crisis.
  • Anticholinergic agents: can mask Parkinsonian symptoms.
  • CNS depressants: increase sedation and dizziness.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: additive blood‑pressure‑lowering effect.
  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Iron or calcium supplements: reduce levodopa absorption; separate dosing times.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed as an adjunct to levodopa therapy for adults with Parkinson's disease. It helps improve motor control, reduces OFF periods, and stabilises the response to levodopa.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its central availability, while Entacapone inhibits COMT, slowing levodopa breakdown and prolonging its effect.

The dose is individualised by the prescribing clinician based on the patient’s disease stage, response to levodopa, and tolerability. Patients should follow the specific regimen provided by their healthcare professional.

Safety data are limited, and the pregnancy category is unknown. The drug should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician before use.

Enquiries are submitted via the product page at gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with levodopa alone, the combination adds Carbidopa to reduce peripheral conversion and Entacapone to inhibit COMT, resulting in higher central levodopa levels, longer duration of action, and often fewer dosing adjustments for motor fluctuations.

Store the tablets at ambient temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use after the expiry date.

The medication is taken orally, usually with food to minimise gastrointestinal upset. Tablets should be swallowed whole with a glass of water; do not crush or chew unless directed by a healthcare professional.

Serious risks include severe dyskinesia, neuroleptic malignant syndrome, marked hypotension, cardiac arrhythmias, and hallucinations or psychosis. Patients should be monitored closely for these events, especially during dose adjustments.

The drug is contraindicated in patients with known hypersensitivity to any component, those taking non‑selective MAO inhibitors, and individuals with narrow‑angle glaucoma. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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