Product image of Levodopa/Carbidopa/Entacapon Heumann (Entacapone, Levodopa, Carbidopa Monohydrate) supplied by GNH India

Levodopa/Carbidopa/Entacapon Heumann

Active Ingredient:
Entacapone, Levodopa, Carbidopa Monohydrate
Origin:
EU

Levodopa/Carbidopa/Entacapon Heumann (Entacapone, Levodopa, Carbidopa Monohydrate)

Levodopa, Carbidopa, and Entacapone, the active ingredients in Levodopa/Carbidopa/Entacapon Heumann, are a dopamine precursor combined with a COMT inhibitor presented as an oral tablet for oral use. It is employed to manage the motor symptoms of Parkinson's disease in adult patients.

GNH India supplies Levodopa/Carbidopa/Entacapon Heumann as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and comprehensive regulatory support throughout the supply chain.

Manufacturer / TM Owner

Abdi Farma, Unipessoal Lda

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease and related motor complications.

  • Parkinson's disease (adjunct to levodopa): enhances central dopamine availability and prolongs levodopa effect, improving motor control.
  • Motor fluctuations in Parkinson's disease: reduces OFF periods and increases ON time without troublesome dyskinesia.
  • Wearing‑off phenomenon in Parkinson's disease: stabilizes dopamine levels to provide more consistent symptom control.

How It Works

  • Levodopa is absorbed and crosses the blood‑brain barrier, where it is decarboxylated to dopamine. Carbidopa inhibits peripheral dopa decarboxylase, preventing premature conversion and increasing central levodopa concentrations. Entacapone blocks catechol‑O‑methyltransferase (COMT) in the periphery, reducing levodopa methylation and extending its plasma half‑life, thereby sustaining dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness or light‑headedness
  • Orthostatic hypotension
  • Headache
  • Insomnia

Serious or Rare Side Effects

  • Dyskinesia or involuntary movements
  • Hallucinations or psychosis
  • Severe hypotension or syncope
  • Cardiac arrhythmias
  • Neuroleptic malignant syndrome
  • Hepatic dysfunction or elevated liver enzymes

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should observe several precautionary measures to ensure patient safety.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially during dose initiation or titration.
  • Liver function assessment: evaluate hepatic enzymes before starting therapy and periodically thereafter.
  • Renal impairment adjustment: consider dose modification in patients with severe renal dysfunction.
  • Cardiac disease caution: use carefully in patients with a history of arrhythmias or ischemic heart disease.
  • Hypersensitivity awareness: discontinue if signs of allergic reaction such as rash, pruritus, or angioedema appear.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic effect and worsen Parkinsonism.
  • Other COMT inhibitors: can lead to excessive levodopa levels.

Moderate Interactions (Monitor Closely)

  • SSRIs and SNRIs: may increase risk of serotonin syndrome.
  • Iron or calcium supplements: can reduce levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensive agents: additive hypotensive effect; monitor blood pressure.
  • High‑protein meals: may compete with levodopa transport, reducing its absorption.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapon Heumann is prescribed as an adjunct to levodopa therapy for adults with Parkinson's disease. It helps improve motor symptoms, reduces OFF periods, and provides more stable control of disease‑related fluctuations.

The combination works on three levels: levodopa is converted to dopamine in the brain; carbidopa blocks peripheral decarboxylation, increasing the amount of levodopa that reaches the central nervous system; and entacapone inhibits the COMT enzyme, slowing levodopa metabolism and extending its therapeutic effect.

The prescribed dose is individualized by the treating physician based on the patient’s disease stage, response to levodopa, presence of motor fluctuations, age, renal and hepatic function, and any concomitant medications. No fixed regimen is provided in public literature.

Safety data for use in pregnancy or lactation are limited, and the product is generally classified as contraindicated unless the potential benefit outweighs the risk. Clinicians should discuss potential hazards with the patient and consider alternative therapies when possible.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Standard levodopa alone is rapidly metabolised, leading to variable plasma levels and frequent OFF periods. Adding carbidopa reduces peripheral conversion, while entacapone further prolongs levodopa’s half‑life by inhibiting COMT. The triple combination therefore offers smoother dopamine delivery, fewer motor fluctuations and often allows lower total levodopa dosing.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf‑life.

The medication is taken orally, usually with a small amount of water. It may be taken with or without food, but patients are advised to avoid high‑protein meals around the dosing time because protein can interfere with levodopa absorption.

Serious adverse events include dyskinesia, hallucinations or psychosis, severe hypotension, cardiac arrhythmias, neuroleptic malignant syndrome, and hepatic dysfunction. Any sudden change in mental status, severe dizziness, or signs of liver injury should prompt immediate medical evaluation.

Patients with known hypersensitivity to levodopa, carbidopa, entacapone or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors, other COMT inhibitors, or those with uncontrolled cardiac arrhythmias unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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