Product image of Levodopa/Carbidopa/Entacapon Macleods (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapon Macleods

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapon Macleods (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, entacapone, the active ingredients in Levodopa/Carbidopa/Entacapon Macleods, are a combination product presented as oral tablets for oral use. They are prescribed to manage Parkinson's disease by improving dopaminergic neurotransmission in patients with motor symptoms.

GNH India supplies Levodopa/Carbidopa/Entacapon Macleods as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Macleods Pharma España, S.L.U

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used within the dopaminergic pathway to manage Parkinson's disease.

  • Parkinson's disease: improves motor symptoms such as bradykinesia, rigidity, and tremor.
  • Parkinson's disease with motor fluctuations: extends the duration of levodopa effect and reduces OFF periods.
  • Early-stage Parkinson's disease: delays the need for higher levodopa doses and helps maintain functional independence.

How It Works

  • The combination delivers levodopa, a dopamine precursor that crosses the blood‑brain barrier, while carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, increasing central levodopa availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), slowing levodopa metabolism and prolonging its plasma half‑life, together enhancing dopaminergic stimulation in the basal ganglia.

Side Effects

Adverse reactions may occur with Levodopa/Carbidopa/Entacapone therapy.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Headache: transient and usually resolves.
  • Insomnia: difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Hallucinations: visual or auditory disturbances.
  • Severe hypotension: marked drop in blood pressure, potentially causing fainting.

Precautions & Warnings

Use of Levodopa/Carbidopa/Entacapone requires careful clinical monitoring.

  • Renal impairment: monitor renal function and adjust therapy if needed.
  • Hepatic impairment: use with caution; liver function should be assessed.
  • Cardiovascular disease: observe blood pressure for orthostatic changes.
  • Psychiatric history: watch for emergence of hallucinations or confusion.
  • Concomitant MAO‑B inhibitors: avoid unless levodopa dose is reduced.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several medicines.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic effect.
  • Anticholinergics: can mask motor symptom changes.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may enhance hypotensive response.
  • SSRIs/SNRIs: potential for serotonin syndrome.
  • Iron or calcium supplements: reduce levodopa absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to treat Parkinson's disease. It helps improve motor symptoms such as tremor, stiffness, and slowness of movement by enhancing dopamine activity in the brain.

Levodopa provides a dopamine precursor that crosses into the brain. Carbidopa blocks peripheral conversion of levodopa, increasing its central availability, while entacapone inhibits the COMT enzyme, prolonging levodopa’s plasma half‑life and sustaining dopaminergic stimulation.

The dose is individualized and set by the prescribing clinician based on disease severity, patient response, and tolerability. Typical regimens involve multiple daily tablets, but exact dosing must follow the prescriber’s instructions.

Safety data are limited, and the medication is generally not recommended during pregnancy or lactation unless the potential benefit outweighs the risk. Clinicians should evaluate each case carefully.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Adding carbidopa reduces peripheral levodopa metabolism, allowing lower doses and fewer side effects, while entacapone further extends levodopa’s half‑life, decreasing motor fluctuations. The combination therefore offers more stable symptom control than levodopa monotherapy.

Store tablets at ambient temperature below 25 °C, in the original container, and protect them from moisture and direct sunlight. Do not use if the packaging is damaged or the tablets appear discolored.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent timing with meals is recommended to maintain stable plasma levels as directed by the prescriber.

Serious adverse events include dyskinesia (involuntary movements), hallucinations or psychosis, severe hypotension leading to fainting, and rare cases of neuroleptic malignant syndrome. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to any component, those currently taking non‑selective MAO inhibitors, or individuals with severe cardiovascular disease, uncontrolled narrow‑angle glaucoma, or a history of malignant neuroleptic reactions should avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Carbidopa, Entacapone, Levodopa

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT