Product image of Levodopa/Carbidopa/Entacapon Stada (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapon Stada

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapon Stada (Carbidopa, Entacapone, Levodopa)

Levodopa, carbidopa, and entacapone, the active ingredients in Levodopa/Carbidopa/Entacapon Stada, are a Levodopa/Carbidopa/Entacapone combination presented as an oral tablet for oral use. The formulation combines a dopamine precursor with peripheral decarboxylase inhibition and COMT inhibition to enhance central dopaminergic activity. They are employed to manage motor symptoms of Parkinson's disease in adult patients.\n\nGNH India supplies Levodopa/Carbidopa/Entacapon Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and regulatory requirements to ensure product integrity across global markets.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

  • Levodopa/Carbidopa/Entacapone is indicated for the treatment of Parkinson's disease, where it helps to improve motor function, reduce OFF episodes, and allow more stable symptom control across disease stages.\n- Early-stage Parkinson's disease: improves tremor, rigidity, and bradykinesia.\n- Advanced Parkinson's disease: reduces OFF periods and motor fluctuations.\n- Fluctuating response to levodopa: enhances and prolongs dopaminergic effect.\n- Adjunct therapy with levodopa: enables lower levodopa dosing while maintaining efficacy.\n- Early morning akinesia: provides smoother onset of motor activity.

How It Works

  • Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is decarboxylated to dopamine. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its availability to the CNS. Entacapone blocks catechol‑O‑methyltransferase (COMT) in the periphery, reducing levodopa metabolism, prolonging its plasma half‑life and enhancing central dopaminergic stimulation.

Side Effects

  • Levodopa/Carbidopa/Entacapone may be associated with a range of adverse reactions.\n\nCommon Side Effects:\n- Nausea\n- Dizziness or light‑headedness\n- Orthostatic hypotension\n- Insomnia\n\nSerious or Rare Side Effects:\n- Severe dyskinesia\n- Neuroleptic malignant syndrome\n- Life‑threatening hypotension\n- Anaphylactic reactions

Precautions & Warnings

  • When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several precautionary measures to ensure safe use.\n- Renal impairment: monitor renal function and adjust therapy as needed.\n- Hepatic impairment: use with caution and observe liver enzymes.\n- Cardiovascular disease: watch for orthostatic hypotension and arrhythmias.\n- Psychiatric history: monitor for hallucinations, confusion, or mood changes.\n- Concomitant MAO‑B inhibitors: avoid co‑administration due to risk of hypertensive crisis.\n- Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

  • Levodopa/Carbidopa/Entacapone can interact with several medicines, affecting its efficacy or safety.\n\nMajor Interactions (Avoid):\n- Non‑selective MAO inhibitors:

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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