Product image of Levodopa + Carbidopa + Entacapona Ciclum (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa + Carbidopa + Entacapona Ciclum

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa + Carbidopa + Entacapona Ciclum (Carbidopa, Entacapone, Levodopa)

Levodopa, the active ingredient in Levodopa + Carbidopa + Entacapona Ciclum, is a dopamine precursor presented as an oral tablet for oral administration. It is combined with carbidopa and entacapone to improve motor symptoms in adults with Parkinson's disease.

GNH India supplies Levodopa + Carbidopa + Entacapona Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is indicated for the management of Parkinson's disease, a neurodegenerative disorder affecting dopaminergic pathways.

  • Parkinson's disease (early stage): improves motor symptoms such as bradykinesia, rigidity and tremor.
  • Parkinson's disease (advanced stage with motor fluctuations): reduces OFF time and prolongs ON periods when used with levodopa.
  • Parkinson's disease (adjunct therapy): enhances overall efficacy of levodopa by increasing its central availability.

How It Works

  • Levodopa is absorbed from the gastrointestinal tract and crosses the blood‑brain barrier, where it is decarboxylated to dopamine. Carbidopa inhibits peripheral dopa decarboxylase, preventing premature conversion and increasing central levodopa levels. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism and extending its plasma half‑life, thereby enhancing dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Dry mouth: reduced salivation causing discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dyskinesia: involuntary movements, often dose‑related.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and rigidity.
  • Severe psychiatric disturbances: hallucinations, delusions or worsening psychosis.
  • Cardiac arrhythmias: uncommon but may occur with pre‑existing heart conditions.
  • Severe hypotension: marked blood pressure decline requiring medical attention.
  • Allergic reactions: rash, pruritus or anaphylaxis in susceptible individuals.

Precautions & Warnings

When prescribing Levodopa/Carbidopa/Entacapone, clinicians should consider several safety measures.

  • Dose titration: adjust gradually based on clinical response and tolerability.
  • Cardiovascular monitoring: observe for orthostatic hypotension and arrhythmias.
  • Psychiatric assessment: monitor for hallucinations, confusion or mood changes.
  • Renal/hepatic function: evaluate before initiation and adjust if impairment is present.
  • Drug interactions: review concomitant medications for potential major or moderate interactions.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several medicines; interactions are categorized by clinical significance.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may cause hypertensive crisis when combined.
  • Antipsychotics with strong dopamine blockade: can markedly reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Iron or vitamin C supplements: may decrease levodopa absorption; separate dosing by at least 2 hours.
  • Antihypertensive agents: additive blood‑pressure‑lowering effect may require dose adjustment.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome, requiring careful monitoring.

Frequently Asked Questions

Levodopa + Carbidopa + Entacapone is an oral combination therapy used to manage the motor symptoms of Parkinson's disease. By increasing central dopamine levels and prolonging levodopa activity, it helps reduce rigidity, tremor, and bradykinesia in adult patients.

Levodopa is converted to dopamine in the brain, providing the neurotransmitter that is deficient in Parkinson's disease. Carbidopa blocks peripheral conversion of levodopa, allowing more to reach the brain, while entacapone inhibits the COMT enzyme, extending levodopa’s plasma half‑life and enhancing its overall efficacy.

The dosage of Levodopa + Carbidopa + Entacapone is individualized. A qualified prescriber determines the appropriate strength, frequency, and titration schedule based on the patient’s disease stage, response to therapy, and tolerability.

Safety data in pregnancy and lactation are limited. The product is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Clinicians should discuss alternatives and weigh risks before prescribing to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levodopa alone is rapidly metabolized, leading to fluctuating plasma levels and motor “OFF” periods. Adding carbidopa reduces peripheral metabolism, and entacapone further prolongs levodopa’s half‑life, resulting in more stable dopamine concentrations, fewer dose adjustments, and improved symptom control.

Store the tablets at ambient temperature below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight. Do not refrigerate or freeze the product.

The medication is taken orally, usually with food or a light snack to reduce gastrointestinal discomfort. Tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious adverse events include neuroleptic malignant syndrome, severe psychiatric disturbances such as hallucinations or psychosis, cardiac arrhythmias, and marked hypotension. Patients should be monitored closely for any sudden changes in mental status, blood pressure or cardiac rhythm.

The combination is contraindicated in patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients. It should also be avoided in individuals taking non‑selective MAO inhibitors or those with narrow‑angle glaucoma, severe hepatic impairment, or a history of malignant neuroleptic syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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