Product image of Levodopa/Carbidopa/Entacapona Cinfa (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa/Carbidopa/Entacapona Cinfa

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa/Carbidopa/Entacapona Cinfa (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Cinfa, is an antiparkinson agent presented as an oral tablet for oral use. It is used to manage Parkinson's disease symptoms in adults, particularly when motor fluctuations occur during levodopa therapy.

GNH India supplies Levodopa/Carbidopa/Entacapone Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is an antiparkinson combination that targets dopamine deficiency in Parkinson's disease.

  • Parkinson's disease (motor fluctuations): improves overall motor control and reduces "off" periods.
  • Parkinson's disease (early morning akinesia): lessens stiffness and difficulty initiating movement.
  • Parkinson's disease (advanced stage): enhances the effectiveness of levodopa therapy and smooths symptom control.

How It Works

  • Levodopa crosses the blood‑brain barrier and is converted to dopamine, restoring deficient neurotransmission. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its central availability. Entacapone blocks catechol‑O‑methyltransferase (COMT), reducing peripheral levodopa metabolism, prolonging plasma half‑life, and enhancing dopaminergic stimulation in the brain.

Side Effects

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: often related to orthostatic changes.
  • Headache: transient and usually resolves.
  • Insomnia: difficulty falling or staying asleep.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Dyskinesia: involuntary, erratic movements.
  • Severe hypotension: may lead to fainting.
  • Psychiatric disturbances: hallucinations or confusion.
  • Cardiac arrhythmias: irregular heart rhythms.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe allergic reactions: rash, swelling, or breathing difficulty.

Precautions & Warnings

Patients should be evaluated for specific health conditions before initiating therapy.

  • Renal impairment: adjust dosing and monitor renal function.
  • Hepatic impairment: use with caution; monitor liver enzymes.
  • Cardiovascular disease: watch for hypotension and arrhythmias.
  • Psychiatric history: assess risk of hallucinations or confusion.
  • Pregnancy and lactation: only use if benefits outweigh risks; consult a specialist.
  • Storage: Store at ambient temperature below 25 °C: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (especially dopamine antagonists): may diminish therapeutic effect.
  • High‑dose pyridoxine (vitamin B6): interferes with levodopa conversion.
  • Certain antihypertensives (e.g., alpha‑blockers): may exacerbate hypotension.
  • SSRIs or SNRIs: increase risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Other dopaminergic agents: may increase dyskinesia.
  • Anticholinergic drugs: additive central nervous system effects.
  • Iron or calcium supplements: reduce levodopa absorption.
  • Protein‑rich meals: compete with levodopa for transport across the gut.
  • Diuretics: may affect electrolyte balance and blood pressure.

Frequently Asked Questions

Levodopa/Carbidopa/Entacapone is prescribed to manage the motor symptoms of Parkinson's disease, especially in patients who experience fluctuations in symptom control while on levodopa therapy.

Levodopa is converted to dopamine in the brain, carbidopa blocks peripheral conversion of levodopa, and entacapone inhibits COMT enzyme, together increasing and prolonging dopamine availability to improve movement control.

The dose is individualized by the prescribing clinician based on disease severity, response to therapy, and patient tolerance. No fixed regimen is provided here.

Safety in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk, and a specialist should be consulted.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with levodopa alone, the addition of carbidopa and entacapone reduces peripheral metabolism, improves symptom stability, and may lower the dose of levodopa needed, while other classes such as dopamine agonists have different side‑effect profiles.

Store the tablets at ambient temperature below 25 °C, in the original packaging, protected from moisture and light to maintain potency.

The medication is taken orally, usually with a glass of water, and may be taken with or without food according to the prescriber's instructions.

Serious risks include dyskinesia, severe hypotension, psychiatric disturbances such as hallucinations, and rare events like neuroleptic malignant syndrome; patients should be monitored closely for these effects.

Patients with known hypersensitivity to any component, those taking non‑selective MAO inhibitors, or individuals with uncontrolled cardiovascular disease should avoid this medication unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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