Product image of Levodopa + Carbidopa + Entacapona Farmoz (Carbidopa, Entacapone, Levodopa) supplied by GNH India

Levodopa + Carbidopa + Entacapona Farmoz

Active Ingredient:
Carbidopa, Entacapone, Levodopa
Origin:
EU

Levodopa + Carbidopa + Entacapona Farmoz (Carbidopa, Entacapone, Levodopa)

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa + Carbidopa + Entacapone Farmoz, is a dopamine precursor with COMT inhibitor presented as a tablet for oral use. It treats Parkinson's disease in adult patients.
GNH India supplies Levodopa + Carbidopa + Entacapone Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Levodopa/Carbidopa/Entacapone is used in the management of Parkinson's disease and related motor complications.

  • Parkinson's disease: improves overall motor symptoms in patients receiving levodopa therapy.
  • Motor fluctuations in Parkinson's disease: reduces OFF periods and prolongs ON time.
  • Early-stage Parkinson's disease: provides smoother dopaminergic stimulation to delay the onset of severe motor symptoms.

How It Works

  • Levodopa is absorbed and crosses the blood‑brain barrier where it is decarboxylated to dopamine, restoring deficient central dopamine levels. Carbidopa inhibits peripheral aromatic L‑amino acid decarboxylase, preventing premature conversion of levodopa and increasing its cerebral availability. Entacapone blocks catechol‑O‑methyltransferase (COMT) in peripheral tissues, reducing levodopa metabolism and further enhancing central dopamine production.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Orthostatic hypotension: drop in blood pressure upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypotension: marked blood‑pressure decline requiring medical attention.
  • Hallucinations or psychosis: visual or auditory disturbances.
  • Dyskinesia: involuntary, erratic movements.
  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and rigidity.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Depression or suicidal thoughts: mood changes requiring evaluation.

Precautions & Warnings

Levodopa/Carbidopa/Entacapone requires careful monitoring due to its pharmacologic profile.

  • Blood pressure monitoring: watch for orthostatic hypotension, especially during dose titration.
  • Psychiatric assessment: observe for hallucinations, confusion, or mood changes.
  • Renal impairment: adjust dose cautiously in patients with reduced kidney function.
  • Cardiovascular disease: use with caution in patients with heart failure or arrhythmias.
  • Concomitant anticholinergics: may mask early signs of toxicity.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levodopa/Carbidopa/Entacapone can interact with several drug classes.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • MAO‑B inhibitors: may potentiate hypertensive episodes.
  • Anticholinergic agents: can mask early signs of levodopa toxicity.
  • Iron or calcium supplements: reduce levodopa absorption.
  • High‑protein meals: compete for intestinal transport, decreasing efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: may enhance hypotensive effects.
  • Antipsychotics (especially dopamine antagonists): can diminish therapeutic response.
  • SSRIs or SNRIs: increase risk of serotonin syndrome when combined with MAO inhibitors.
  • CYP2D6 inhibitors: may alter metabolism of concomitant medications.
  • Diuretics: may exacerbate electrolyte imbalances affecting blood pressure.

Frequently Asked Questions

Levodopa + Carbidopa + Entacapone is prescribed to manage Parkinson's disease, particularly to improve motor symptoms and reduce the frequency of OFF periods that can occur with levodopa monotherapy.

Levodopa is converted to dopamine in the brain, restoring deficient neurotransmission. Carbidopa blocks peripheral conversion of levodopa, increasing its availability to the central nervous system, while Entacapone inhibits the COMT enzyme, reducing peripheral metabolism and prolonging levodopa’s effect.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s disease stage, response, and tolerability. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use only if the potential benefit justifies the potential risk, and discuss with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with levodopa alone, the addition of Carbidopa reduces peripheral conversion, and Entacapone further decreases metabolism, resulting in more stable plasma levels, fewer OFF episodes, and often a lower total levodopa requirement.

Store the tablets at room temperature, below 25 °C, in the original blister pack. Protect them from moisture and direct sunlight to maintain potency throughout the shelf life.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals helps maintain stable absorption.

Serious risks include severe hypotension, hallucinations or psychosis, dyskinesias, neuroleptic malignant syndrome, and rare allergic reactions. Patients should be monitored closely for these events, especially during dose changes.

Patients with known hypersensitivity to any component, those taking non‑selective MAO inhibitors, or individuals with severe cardiovascular disease should avoid this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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